抗生物質の予行治療によるまたはそれなしの慢性ダクリオシスティス症の患者における眼内微生物群のタイプおよび縦線微生物群の変化
Shengru Wu1,2, Limin Zhu3, Tingting Wang3,4
1College of Animal Science and Technology Northwest A&F University Yangling China.
まとめ
慢性ダクリオシスティス (DC) の抗生物質前治療は,眼球の微生物群を乱す可能性があります. この研究では,特に重症でない症例では,回復率は類似しているため,ダクリオシストロニノストミー前に必要ないかもしれないことを示唆しています.
科学分野:
- オフタルモロジック (眼科)
- 微生物学 微生物学とは
- 手術研究の研究について
背景:
- 慢性ダクリオシスティス (DC) の管理には,ダクリオシストロニノストミー前の抗生物質の予備治療がしばしば含まれます.
- この抗生物質の前処理が眼や鼻の微生物群に与える影響は,まだ完全に理解されていません.
研究 の 目的:
- DCのためにダクリオシストロニノストミーを受けている患者の眼と鼻の微生物群に対する抗生物質の予行治療の縦方向効果を評価する.
- 抗生物質前治療を受けたDC患者と未受治療のDC患者,および健康な対照群との間で,微生物群の組成と回復結果を比較する.
主な方法:
- 33人のDC患者 (抗生物質前治療と/なし) から外科手術前と1,2,4週間の経緯に沿って結膜と鼻のスランプを採取した.
- 46人の健康なボランティアと他の眼疾患を持つ14人の患者から結膜袋のスランプを採取した.
- 眼/鼻の微生物群の多様性,豊かさ,および組成,臨床回復率の比較分析.
主要な成果:
- 抗生物質の予備治療を受けていないDC患者は,健康な対照群と比較して,手術前より大きな眼球微生物群多様性を示しました.
- 臨床回復率は類似していたが,抗生物質の治療前治療は,手術後4週間で眼球の微生物群の豊かさと多様性を著しく変化させた.
- 眼球の微生物群は,抗生物質の予備治療を受けた患者でより混乱していました.
結論:
- ダクリオシストロヒノストミー前の抗生物質の予行治療は,眼球の微生物群の組成に重大な障害をもたらす可能性があります.
- 抗生物質の予備治療を怠ることで,臨床的回復結果は悪影響を受けるようには見えません.
- 抗生物質の前治療は,特に重症でない症例では,DC患者のために必要ない場合がありますので,現在の臨床プロトコルの再評価を正当化します.
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