関連する実験動画

Updated: Feb 13, 2026

SorLA and CLC:CLF-1-dependent Downregulation of CNTFRα as Demonstrated by Western Blotting, Inhibition of Lysosomal Enzymes, and Immunocytochemistry
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SorLA and CLC:CLF-1-dependent Downregulation of CNTFRα as Demonstrated by Western Blotting, Inhibition of Lysosomal Enzymes, and Immunocytochemistry

Published on: January 6, 2017

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リソソマ・プロテアゼ媒介のAPP分解はpHに依存し,変異に敏感であり,タウタンパク質分解を促進する

Caroline Ackley1, Zoe Liau1,2, Shruti Arya1

  • 1Edward and Pearl Fein Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, 100190 California USA.

Molecular neurodegeneration advances
|February 12, 2026
PubMed
まとめ

この研究は,リゾソーム酵素がアミロイド前駆タンパク質 (APP) とその変種を処理し,APPとタウ分裂を結びつけ,新しいアルツハイマー病 (AD) 治療標的を示唆することを明らかにしています.

キーワード:
A. A. A. A. でした.APP APP APP APP APP APP APP APP APP APP APP APP APP APP APP APP APP APP APP APP APP APP APP APP APP APP APP APPアルツハイマー病 (Alzheimer's disease) とは,アルツハイマー病 (Alzheimer's disease) とは,アルツハイマー病 (Alzheimer's disease) とは,アルツハイマー病 (Alzheimer's disease) とは,アミロイドベータはアミロイド前身タンパク質の前身タンパク質である.オートファギー (自食) とはキャセプシン (Cathepsin) とはライソソームはライソソームである.ニューロンの変性です.プロテアゼプロテアゼとはタウ・タウ・タウとは

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