Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Proteomics01:33

Proteomics

9.9K
A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
9.9K
Drug Discovery: Overview01:26

Drug Discovery: Overview

11.9K
Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
11.9K
Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

924
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
924
Protein-protein Interfaces02:04

Protein-protein Interfaces

14.8K
Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a...
14.8K
Protein and Protein Structure02:15

Protein and Protein Structure

88.9K
Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
A protein's shape is critical to its function. For example, an enzyme...
88.9K
Conservation of Protein Domains Over Different Proteins02:26

Conservation of Protein Domains Over Different Proteins

14.7K
Protein domains are small structurally independent units that are part of a single amino acid chain.  Although these domains are often structurally independent, they may rely on synergistic effects to perform their functions as part of a larger protein. Protein domains may be conserved within the same organism, as well as across different organisms.
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to...
14.7K

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

The promising applications of 3D printing technology for diagnosis and therapy of cancer: Recent advances and challenges.

BioImpacts : BI·2026
Same author

Mucoadhesive TMC-coated solid lipid nanoparticles for oral co-delivery of docetaxel and curcumin: formulation optimization, in vitro characterization, and cytotoxic evaluation.

3 Biotech·2026
Same author

Neuroimaging-based subtyping of migraine identifies clinically distinct phenotypes.

Cephalalgia : an international journal of headache·2026
Same author

Adaptive laboratory evolution of Saccharomyces cerevisiae CEN.PK 113-7D to enhance ethanol tolerance.

FEMS yeast research·2025
Same author

Personal Activity Trackers and Family Engagement in a Pediatric Obesity Intervention: Randomized Controlled Trial.

JMIR formative research·2025
Same author

Tailoring Carbon Quantum Dots via Precursor Engineering for Fluorescence-Based Biosensing of <i>E. coli</i>.

Biosensors·2025

関連する実験動画

Updated: Feb 13, 2026

Author Spotlight: Advancing the Analysis of Plasma Extracellular Vesicle Proteome for Cardiovascular Biomarker Studies
05:30

Author Spotlight: Advancing the Analysis of Plasma Extracellular Vesicle Proteome for Cardiovascular Biomarker Studies

Published on: January 31, 2025

1.1K

タンパク質バイオマーカーの発見におけるプロテオミックスの技術

Mahsa Babaei1, Soheila Kashanian2,3, Huang-Teck Lee4

  • 1Department of Biology Faculty of Science Razi University Kermanshah Iran.

Quantitative biology (Beijing, China)
|February 12, 2026
PubMed
まとめ

タンパク質バイオマーカーは,がんの診断に不可欠です. この研究では,質量スペクトロメトリや免疫測定などのプロテオミクス技術を使用して,これらのバイオマーカーの発見,検証,検証の進展をレビューしています.

キーワード:
バイオマーカーの発見癌のバイオマーカーである.ゲルベースの方法ゲルフリーメソッドはゲルフリーメソッドです.質量スペクトル顕微鏡法による質量スペクトル顕微鏡法プロテオミクスプロテオミクス

さらに関連する動画

Low Molecular Weight Protein Enrichment on Mesoporous Silica Thin Films for Biomarker Discovery
13:00

Low Molecular Weight Protein Enrichment on Mesoporous Silica Thin Films for Biomarker Discovery

Published on: April 17, 2012

14.0K
Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer
13:19

Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer

Published on: November 2, 2013

17.2K

関連する実験動画

Last Updated: Feb 13, 2026

Author Spotlight: Advancing the Analysis of Plasma Extracellular Vesicle Proteome for Cardiovascular Biomarker Studies
05:30

Author Spotlight: Advancing the Analysis of Plasma Extracellular Vesicle Proteome for Cardiovascular Biomarker Studies

Published on: January 31, 2025

1.1K
Low Molecular Weight Protein Enrichment on Mesoporous Silica Thin Films for Biomarker Discovery
13:00

Low Molecular Weight Protein Enrichment on Mesoporous Silica Thin Films for Biomarker Discovery

Published on: April 17, 2012

14.0K
Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer
13:19

Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer

Published on: November 2, 2013

17.2K

科学分野:

  • バイオケミストリー バイオケミストリー
  • プロテオミクスはプロテオミクスを用います.
  • 癌診断 癌診断について

背景:

  • タンパク質バイオマーカーは,50年以上にわたり,がんの診断と治療において不可欠な役割を果たしてきました.
  • プロテオミクスの進歩により,様々な疾患に対する数千の潜在的なタンパク質バイオマーカーが得られました.
  • プロテオミクスの診断は,先端技術を用いたサンプルの前処理,浄化,分析を伴う.

研究 の 目的:

  • タンパク質バイオマーカーの発見,検証,検証における最近の改善を調査する.
  • 従来のプロテオミクス技術のメリット・デメリットについて議論する.
  • バイオマーカーの開発における質量スペクトロメトリーやその他の方法の役割を強調する.

主な方法:

  • タンパク質の識別と定量化のために利用された質量スペクトロメトリー (MS).
  • 複数の反応モニタリング (MRM),並列反応モニタリング (PRM),およびバイオマーカー検証のための選択反応モニタリング (SRM) を調査した.
  • バイオマーカーの検証のための酵素関連免疫吸収検査 (ELISA) を検討.

主要な成果:

  • マススペクトロメトリーは,候補バイオマーカーを特定し,定量化するための重要な技術です.
  • 検証と検証は,特に大きなサンプルセットでは,偽陽性を最小限に抑えるために,発見後に不可欠です.
  • MRM,PRM,安定した同位体ラベル付きの内部規格を持つSRM,ELISAは,検証と検証の重要な方法である.

結論:

  • 最近の改良により,タンパク質バイオマーカーの発見と検証の信頼性が向上しています.
  • 精密な検証・検証技術の選択は,がんの正確な診断に不可欠です.
  • この研究は,臨床応用におけるプロテオミクスの進化の景観についての洞察を提供します.