カンジデミアの眼科評価と臨床結果: 7年間の遡及的マルチセンターコホート研究
Hanne Lamberink1,2, Shantelle A E Ortega1, Isa M Schellekens1
1Department of Internal Medicine, Section of Infectious Diseases, Erasmus University Medical Center, Rotterdam, The Netherlands.
Open forum infectious diseases
|February 12, 2026
まとめ
眼球カンジダイアシス (OC) は,カンジデミア患者の約5%に影響を与え,しばしば症状がありません. カンジデミアの症例における迅速なフォンドスコピーは,抗真菌治療をガイドし,視力喪失を予防します.
科学分野:
- オフタルモロジック (眼科)
- 感染症 感染症は感染症です.
- 医学菌学 医学菌学について
背景:
- 眼球カンジディアシス (OC) は,カンジデミアの深刻な合併症です.
- 現在,カンジデミア患者におけるフォンドスコピクスクリーニングに関するガイドラインは,矛盾しています.
- この研究は,オランダのコホートにおけるOCの発生率と影響を調査しています.
研究 の 目的:
- ファンドスコピーを受けるカンジデミア患者におけるOCの頻度を測定する.
- 抗真菌治療の選択と期間に対するOCの影響を評価する.
- OC患者における持続的な視力喪失の発生率を評価する.
主な方法:
- カンジデミアの成人の患者による遡及的なコホート研究.
- 含有基準: *Candida* 種の血液培養が陽性であった.
- 患者の76.4%でファンドスコピーを実施した;OCはコリオレチニティスまたはエンドファルミティスとして定義された.
主要な成果:
- 眼球カンジダ症は,フォンドスコピーを受けた患者の4.9%で診断されました.
- 60%のOC患者は無症状であったか,症状を報告することができなかった.
- フォンドスコピーの発見は,15人のOC患者全員の抗真菌療法に変化をもたらし,治療の延長とスイッチを含む.
結論:
- 眼球カンジディアシスは珍しいが,カンジデミアでは臨床的に有意である.
- 鏡検査の結果は,抗真菌治療の決定を導く上で極めて重要です.
- 持続的な視力喪失はまれで,OC患者の20%で発生しました.
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