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脊髄外科手術を受けた高血圧患者のレミマゾラムとプロポポールの低血圧発生率の比較

Jing Cui¹, Xinyu Qi¹, Junjie Wang¹

¹Department of Anesthesiology, Peking University International Hospital Beijing 102206, China.

American journal of translational research

|February 12, 2026

まとめ

レミマゾラムは,プロポフォールと比較して,脊髄外科手術を受けた高血圧患者において,低血圧の発生率が低く,PONVや注射痛などの有害事象が少ないことを示した. これは,レミマゾラームが,この患者グループにとってより安全な麻酔剤の選択である可能性があることを示唆しています.

科学分野:

アネステシオロジーアネステシオロジー
心血管麻酔は,心血管麻酔というものです.
神経外科は神経外科です.

背景:

脊髄外科手術を受ける高血圧患者は,手術中の低血圧のリスクが高くなります.
プロポフォールは一般的な麻酔薬ですが,その使用は血液動力学的不安定性に関連することがあります.
レミマゾラムは,より新しい超短期間作用ベンゾジアゼピンであり,血液動力学的管理において潜在的な利点を提供しています.

研究の目的:

脊髄外科手術を受ける高血圧患者のレミサゾラムとプロポフォールの間での手術中の低血圧の発生率を比較する.
各麻酔剤に関連した術後の有害事象を評価するために.

主な方法:

脊髄外科手術を受けた194人の高血圧患者の遡及的分析.
患者は,レミマゾラム (n=99) またはプロポホル (n=95) を主麻酔薬として投与された.
術内低血圧は,平均動脈圧 (MAP) <基値の80%と定義され,重度の低血圧は,MAP <基値の70%と定義される.

主要な成果:

レミマゾラム群 (82.83%) とプロポフォール群 (93.68%) (P=0.019) の間で低血圧の発生率が低かった.
レミマゾラムグループは,手術後の吐き気と嘔吐 (PONV) の割合が有意に低い (15.15%対29.47%,P=0.016) と注射痛 (2.02%対26.32%,P<0.001) でした.
レミマゾラムは低血圧に対する独立した保護因子であった (OR=0.435,95%CI:0.210-0.901,P=0.025).

結論:

レミマゾラムは,プロポフォールと比較して,脊髄外科手術を受ける高血圧患者の手術中の低血圧のリスクが著しく低いと関連しています.
レミマゾラムの使用は,PONVおよび注射痛を含む術後の有害事象の減少をもたらしました.
レミマゾラムは,脊髄手術を受ける高血圧患者にとって,より安全な麻酔の選択肢を提示する可能性があります.

キーワード:

脊髄外科手術脊髄外科手術脊髄外科手術脊髄外科手術低血圧低血圧は,低血圧状態からプロポフォール (Propofol) とはレミマゾラームは,レミマゾラームとは

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