Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Single Nucleotide Polymorphisms-SNPs01:05

Single Nucleotide Polymorphisms-SNPs

18.6K
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
18.6K
Epistasis01:39

Epistasis

50.3K
In addition to multiple alleles at the same locus influencing traits, numerous genes or alleles at different locations may interact and influence phenotypes in a phenomenon called epistasis. For example, rabbit fur can be black or brown depending on whether the animal is homozygous dominant or heterozygous at a TYRP1 locus. However, if the rabbit is also homozygous recessive at a locus on the tyrosinase gene (TYR), it will have an unshaded coat that appears white, regardless of its TYRP1...
50.3K
Epistasis Analysis01:09

Epistasis Analysis

5.8K
Although Mendel chose seven unrelated traits in peas to study gene segregation, most traits involve multiple gene interactions that create a spectrum of phenotypes. When the interaction of various genes or alleles at different locations influences a phenotype, this is called epistasis. Epistasis often involves one gene masking or interfering with the expression of another (antagonistic epistasis). Epistasis often occurs when different genes are part of the same biochemical pathway. The...
5.8K
Nucleotide Excision Repair01:08

Nucleotide Excision Repair

40.9K
Overview
40.9K
Nucleotide Excision Repair01:38

Nucleotide Excision Repair

5.3K
DNA Distortion and Damage
Cells are regularly exposed to mutagens—factors in the environment that can damage DNA and generate mutations. UV radiation is one of the most common mutagens and is estimated to introduce a significant number of changes in DNA. These include bends or kinks in the structure, which can block DNA replication or transcription. If these errors are not fixed, the damage can cause mutations, which in turn can result in cancer or disease depending on which sequences are...
5.3K
Model Approaches for Pharmacokinetic Data: Physiological Models01:15

Model Approaches for Pharmacokinetic Data: Physiological Models

281
Physiological models in pharmacokinetics are instrumental in understanding the distribution and elimination of drugs within the body. These models describe the drug concentration within target organs, influenced by factors such as drug uptake, tissue volume, and blood flow. Drug uptake is governed by the partition coefficient, which signifies the drug concentration ratio in tissue to that in the blood. The blood flow rate to a specific tissue is expressed as Qt, and the rate of change in tissue...
281

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Exploring Complex Genetic Mechanisms in Brain Imaging Genetics via a New Multi-task Learning Method.

IEEE transactions on computational biology and bioinformatics·2026
Same author

stDGCN: A dual-augmentation graph convolutional network for identifying spatial domains with attention mechanism.

IEEE journal of biomedical and health informatics·2026
Same author

STNMAE: Identifying Spatial Domains from Spatial Transcriptomics Data with Neighbor-Aware Multi-view Masked Graph Autoencoder.

Interdisciplinary sciences, computational life sciences·2026
Same author

SpaVGMC: A Unified Representation Learning Framework via Structural and Semantic Alignment in Spatial Transcriptomics.

Journal of chemical information and modeling·2026
Same author

MHNNMDA: multi-stage hypergraph neural network for predicting miRNA-disease association types.

Journal of computer-aided molecular design·2026
Same author

Prediction of multicategory miRNA-disease associations based on bidirectional hypergraph attention network and gated convolutional strategy.

Journal of computer-aided molecular design·2026

関連する実験動画

Updated: Feb 13, 2026

Genotyping Single Nucleotide Polymorphisms in the Mitochondrial Genome by Pyrosequencing
07:24

Genotyping Single Nucleotide Polymorphisms in the Mitochondrial Genome by Pyrosequencing

Published on: February 10, 2023

2.0K

SimHOEPI:高次元のエピスタシスモデルで単一ヌクレオチドポリモルフィズムデータを生成するための再サンプリングシミュレータ.

Yahan Li1, Xinrui Cai1, Junliang Shang1

  • 1School of Computer Science Qufu Normal University Rizhao China.

Quantitative biology (Beijing, China)
|February 12, 2026
PubMed
まとめ

SimHOEPIは,遺伝子研究のための新しいシミュレータで,高次元のエピスタシスモデルのための独立したシミュレーションデータを生成します. このツールは,複雑な疾患に対する全ゲノム関連研究 (GWAS) の評価に役立ちます.

キーワード:
高級エピスタシスモデルモデル入口テーブルは,入口テーブルです.再サンプリング戦略シミュレーション・シミュレーションシングルヌクレオチドポリモルフィズムである.

さらに関連する動画

The Visual Colorimetric Detection of Multi-nucleotide Polymorphisms on a Pneumatic Droplet Manipulation Platform
10:01

The Visual Colorimetric Detection of Multi-nucleotide Polymorphisms on a Pneumatic Droplet Manipulation Platform

Published on: September 27, 2016

8.0K
Author Spotlight: Genetic Profiling for Fluorouracil Response in Gastric Cancer
06:21

Author Spotlight: Genetic Profiling for Fluorouracil Response in Gastric Cancer

Published on: May 10, 2024

1.3K

関連する実験動画

Last Updated: Feb 13, 2026

Genotyping Single Nucleotide Polymorphisms in the Mitochondrial Genome by Pyrosequencing
07:24

Genotyping Single Nucleotide Polymorphisms in the Mitochondrial Genome by Pyrosequencing

Published on: February 10, 2023

2.0K
The Visual Colorimetric Detection of Multi-nucleotide Polymorphisms on a Pneumatic Droplet Manipulation Platform
10:01

The Visual Colorimetric Detection of Multi-nucleotide Polymorphisms on a Pneumatic Droplet Manipulation Platform

Published on: September 27, 2016

8.0K
Author Spotlight: Genetic Profiling for Fluorouracil Response in Gastric Cancer
06:21

Author Spotlight: Genetic Profiling for Fluorouracil Response in Gastric Cancer

Published on: May 10, 2024

1.3K

科学分野:

  • 遺伝学とバイオインフォマティクス
  • コンピュータ生物学 コンピュータ生物学

背景:

  • エピスタシス,遺伝子相互作用は,複雑な疾患の遺伝性を理解する鍵です.
  • 全ゲノム関連研究 (GWAS) は,ツール評価のために強力なシミュレーションデータが必要です.
  • 既存の遺伝子シミュレータは,高次元のエピスタシスと独立したデータ生成をサポートしていません.

研究 の 目的:

  • 高級エピスタシスの新型シミュレータであるSimHOEPIを紹介します.
  • 現在の遺伝子シミュレーションツールの限界に対処する.
  • GWASにおけるエピスタシスの正確な検出を容易にする.

主な方法:

  • 高級エピスタシスモデルのための貫通度表を計算するためにSimHOEPIを開発しました.
  • 独立したシミュレーションデータ生成のための再サンプリング戦略を実施しました.
  • リアルなマイナーアレル周波数と正確なエピスタシスモデルの埋め込みが保存されています.

主要な成果:

  • SimHOEPIは,高級エピスタシスの独立したシミュレーションSNPデータを成功裏に生成しています.
  • シミュレータは,現実的なアレル周波数と正確なモデル統合を維持しています.
  • 複雑な遺伝子モデルの許容可能なシミュレーション時間を達成しました.

結論:

  • SimHOEPIは,複雑なエピスタシスの遺伝データをシミュレートするための実行可能な代替案を提供します.
  • このツールは,GWASにおけるエピスタシス検出方法の評価を強化します.
  • 複雑な疾患の遺伝的基礎に関する研究を促進します.