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Updated: Feb 13, 2026

Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models
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APOEは,mTOR/Stat3シグナル伝達経路を通じてフェロプトーシスを調節することにより,骨肉肉腫を抑制する

Xiangyang Cheng1, Chong Bian1, Yiming Zhang1

  • 1Department of Orthopedics, Minhang Hospital, Fudan University, Minhang District, Shanghai, China.

Archives of medical science : AMS
|February 12, 2026
PubMed
まとめ

アポリポプロテインE (APOE) の過剰発現は,フェロプトーシスとオートファギーを促進することによって,骨肉肉腫 (OS) の成長を阻害する. この発見は,この攻撃的な骨癌の治療のための有望な治療目標を提供します.

キーワード:
アポエ (アポエ) とはオートファジー (Autophagy) とはフェロプトーシス (ferroptosis) とはmTOR/Stat3シグナル伝達経路についてオステオサルコマ (Osteosarcoma) とは

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