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Updated: Feb 13, 2026

Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR
13:04

Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR

Published on: March 1, 2019

9.4K

CRISPRベースの遺伝子活性化に対するgRNAの不一致性耐性は,細胞再プログラムに不可欠な広範な活動を授与します

Samuel J Reisman, Wei Zhu, Samantha E Miller

    bioRxiv : the preprint server for biology
    |February 12, 2026
    PubMed
    まとめ

    特定のCRISPR活性化ガイドRNA (gRNA) は,何千もの遺伝子に影響を及ぼし,標的外結合を広範囲にわたって行い,予期せぬ形でアストロサイトを再プログラムした. この乱交的なgRNAは,ガイドRNA配列が結合にどのように影響するかを明らかにし,広範な細胞ネットワークの再プログラムに活用することができます.

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