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関連する概念動画

Inheritance of Chromatin Structures03:17

Inheritance of Chromatin Structures

7.6K
Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying...
7.6K
Chromatin Structure Regulates pre-mRNA Processing02:41

Chromatin Structure Regulates pre-mRNA Processing

8.3K
In eukaryotic cells, nascent mRNA transcripts need to undergo many post-transcriptional modifications to reach the cell cytoplasm and translate into functional proteins. For a long time, transcription and pre-mRNA processing were considered two independent events that occur sequentially in the cell. However, it has now been well established that transcription and pre-mRNA processing are two simultaneous processes that are precisely regulated inside the cell.
The chromatin structure, especially...
8.3K
Duplication of Chromatin Structure02:05

Duplication of Chromatin Structure

7.4K
The process of chromosome duplication during cell division requires genome-wide disruption and re-assembly of chromatin. The chromatin structure must be accurately inherited, reassembled, and maintained in the daughter cells to ensure lineage propagation.
The basic unit of the chromatin is the nucleosome, consisting of DNA wrapped around octameric histone proteins and short stretches of linker DNA separating individual nucleosomes. The histone proteins within the nucleosome have their...
7.4K
Chromatin Packaging02:21

Chromatin Packaging

22.3K
Each human somatic cell contains 6 billion base-pairs of DNA. Each base-pair is 0.34 nm long, which means that each diploid cell contains a staggering 2 meters of DNA. How is such a long DNA strand packed inside a nucleus measuring only 10 - 20 microns in diameter? 
The chromatin
In combination with specialized DNA binding protein called Histones, the DNA double helix forms a compact DNA: protein complex called chromatin. The chromatin itself is further compacted into higher-order...
22.3K
Spreading of Chromatin Modifications02:25

Spreading of Chromatin Modifications

9.5K
The histone proteins in the nucleosomes are post-translationally modified (PTM) to increase or decrease access to DNA. The commonly observed PTMs are methylation, acetylation, phosphorylation, and ubiquitination of lysine amino acids in the histone H3 tail region. These histone modifications have specific meaning for the cell. Hence, they are called "histone code". The protein complex involved in histone modification is termed as "reader-writer" complex.
Writers
The writer...
9.5K
Chromatin Structure and RNA Splicing02:41

Chromatin Structure and RNA Splicing

3.5K
3.5K

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関連する実験動画

Updated: Feb 13, 2026

CRISPR-Mediated Reorganization of Chromatin Loop Structure
09:20

CRISPR-Mediated Reorganization of Chromatin Loop Structure

Published on: September 14, 2018

13.1K

CTCF媒介のクロマチンの組織化の構造的基礎

Manuel Osorio Valeriano, Alexander C Stone, Masahiro Nagano

    bioRxiv : the preprint server for biology
    |February 12, 2026
    PubMed
    まとめ
    この要約は機械生成です。

    CCCTC結合因子 (CTCF) は,ゲノム相互作用と細胞の微分化に不可欠な核粒子のオリゴメリゼーションを通じて染色体構造を組織します. CTCFの相互作用の障害は,遺伝子発現と細胞発達の悪影響を及ぼします.

    さらに関連する動画

    Deciphering High-Resolution 3D Chromatin Organization via Capture Hi-C
    09:32

    Deciphering High-Resolution 3D Chromatin Organization via Capture Hi-C

    Published on: October 14, 2022

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    Isolation and Characterization of Mouse Antral Oocytes Based on Nucleolar Chromatin Organization
    07:16

    Isolation and Characterization of Mouse Antral Oocytes Based on Nucleolar Chromatin Organization

    Published on: January 7, 2016

    14.1K

    関連する実験動画

    Last Updated: Feb 13, 2026

    CRISPR-Mediated Reorganization of Chromatin Loop Structure
    09:20

    CRISPR-Mediated Reorganization of Chromatin Loop Structure

    Published on: September 14, 2018

    13.1K
    Deciphering High-Resolution 3D Chromatin Organization via Capture Hi-C
    09:32

    Deciphering High-Resolution 3D Chromatin Organization via Capture Hi-C

    Published on: October 14, 2022

    4.5K
    Isolation and Characterization of Mouse Antral Oocytes Based on Nucleolar Chromatin Organization
    07:16

    Isolation and Characterization of Mouse Antral Oocytes Based on Nucleolar Chromatin Organization

    Published on: January 7, 2016

    14.1K

    科学分野:

    • 分子生物学は分子生物学である.
    • ゲノミクスゲノミクスとは
    • 構造生物学 構造生物学とは

    背景:

    • ユカリオットDNAの組織化は,ゲノムの安定性,遺伝子調節,再結合に不可欠である.
    • CCCTC結合因子 (CTCF) は,クロマチンのループとエンハンサー・プロモーターの隔離に関与する重要なタンパク質です.
    • CTCFの部位の周りのクロマチンのパターンの正確な役割は,ほとんど不明のままです.

    研究 の 目的:

    • CTCFがクロマチンを組織する構造的メカニズムを解明する.
    • CTCF媒介のクロマチンの上位階構造の機能的意義を調査する.
    • ゲノム組織と細胞プロセスにおけるCTCF相互作用の役割を理解する.

    主な方法:

    • 再構成されたCTCF-ニュクレオソーム複合体の冷凍電子顕微鏡 (冷凍-EM) です.
    • 異なるDNA基板のオリゴメリゼーションを評価するための生化学的分析.
    • CTCF-CTCFの相互作用を妨害することの影響を研究するためのセルラーアッセイ.

    主要な成果:

    • CTCF二酸化は,ヒストン-ヒストンおよびCTCF-CTCF相互作用を通じて,核細胞のオリゴメリゼーションをより高次のアセンブリに駆動します.
    • CTCFのオリゴメリゼーションは,裸のDNAではなく,染色化されたDNAに依存しています.
    • 細胞内のCTCF-CTCFインターフェースを破壊すると,クロマチンのループが減り,細胞の分化が損なわれます.

    結論:

    • CTCFの部位におけるクロマチンの構造は,遠隔ゲノム領域間の高次元の相互作用を媒介するために重要である.
    • CTCF媒介の染色体組織は,細胞型特異的な遺伝子発現と分化をサポートするために不可欠です.
    • CTCF-CTCFの相互作用は,ゲノム構造と機能の確立と維持に不可欠です.