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関連する概念動画

RNA Editing02:23

RNA Editing

9.9K
RNA editing is a post-transcriptional modification where a precursor mRNA (pre-mRNA) nucleotide sequence is changed by base insertion, deletion, or modification. The extent of RNA editing varies from a few hundred bases, in mitochondrial DNA of trypanosomes, to a just single base, in nuclear genes of mammals. Even a single base change in the pre-mRNA can convert a codon for one amino acid into the codon for another amino acid or a stop codon. This type of re-coding can significantly affect the...
9.9K
RNA Structure01:23

RNA Structure

79.2K
Overview
The basic structure of RNA consists of a five-carbon sugar and one of four nitrogenous bases. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA): messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three RNA types consist of a...
79.2K
RNA Structure01:19

RNA Structure

7.7K
The basic structure of RNA consists of a string of ribonucleotides attached by phosphodiester bonds. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA) involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three...
7.7K
Self-Awareness and Its Effects01:21

Self-Awareness and Its Effects

318
Self-awareness is a psychological state in which the individual becomes the focal point of their attention. This inward focus transforms the self into an object of contemplation and assessment, influencing how individuals perceive their actions and their alignment with personal and societal standards.Triggers and Contexts for Self-AwarenessSelf-awareness can be activated by external stimuli that make individuals visually or audibly aware of themselves, such as mirrors, cameras, or recordings.
318
Altered States of Awareness01:06

Altered States of Awareness

1.2K
Altered states of consciousness represent significant deviations from one's normal mental state. These deviations can range from subtle changes in awareness to profound transformations in perception, thought processes, and sensory experiences. Altered states of consciousness can be triggered by various factors, including drug use, meditation, hypnosis, illness, or even intense fatigue.
The ingestion of substances like stimulants or hallucinogens leads to chemical alterations in the brain...
1.2K
Subconsciousness and No Awareness01:15

Subconsciousness and No Awareness

721
The concept of subconscious awareness refers to the processing of information below the level of conscious thought, which significantly influences both behaviors and decisions. It is also known as waking subconscious awareness. This complex level of cognition operates without the direct awareness of the individual, facilitating rapid and simultaneous handling of multiple information streams.
An illustrative example of subconscious processing is its role in problem-solving. Often, individuals...
721

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関連する実験動画

Updated: Feb 13, 2026

RNA Secondary Structure Prediction Using High-throughput SHAPE
13:42

RNA Secondary Structure Prediction Using High-throughput SHAPE

Published on: May 31, 2013

32.3K

構造に敏感なグラフ学習は,組織や種にまたがってRNAの編集性を予測します.

Zohar Rosenwasser, Michael Levitt, Erez Y Levanon

    bioRxiv : the preprint server for biology
    |February 12, 2026
    PubMed
    まとめ

    ADAR酵素によるRNA編集を予測することは困難です. 新しいグラフ注意フレームワークであるA dar E ditは,配列ベースのモデルを上回るRNA構造を考慮してRNA編集部位を正確に予測します.

    科学分野:

    • バイオケミストリー バイオケミストリー
    • コンピュータ生物学 コンピュータ生物学
    • ゲノミクスゲノミクスとは

    背景:

    • ADAR酵素によって媒介されるアデノシン-イノシン (A-to-I) RNA編集は,治療的可能性を秘めた重要な転写後の改変である.
    • A-to-I編集部位を予測するのは,単に配列ではなく,二重鎖RNA (dsRNA) の幾何学と安定性に依存しているため難しい.
    • 現在のモデルは,ADAR酵素認識の複雑な構造的決定因子を捉えるのに苦労しています.

    研究 の 目的:

    • A-to-I RNA編集サイトを予測するための構造明示的なコンピューティングフレームワークを開発する.
    • dsRNAの構造的特徴を組み込むことにより,RNA編集の予測の精度を向上させる.
    • 異なる種間のADAR基板認識の保存原理を調査する.

    主な方法:

    • A dar E dit を開発し,dsRNA サブストラットをバックボーンとベースペアのエッジを持つ核酸グラフとして表現するグラフ注意枠である.
    • タイプされた相互作用とモチーフに敏感なシーケンスブランチでグラフ表現を拡張しました.
    • RNAfoldで予測された二次構造とGTEx RNA-seqデータを使用して,ヒトの逆転Aluデュプレックスでモデルをトレーニングし,評価しました.

    主要な成果:

    さらに関連する動画

    A Nonsequencing Approach for the Rapid Detection of RNA Editing
    08:50

    A Nonsequencing Approach for the Rapid Detection of RNA Editing

    Published on: April 21, 2022

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    RNA Catalyst as a Reporter for Screening Drugs against RNA Editing in Trypanosomes
    09:19

    RNA Catalyst as a Reporter for Screening Drugs against RNA Editing in Trypanosomes

    Published on: July 22, 2014

    8.8K

    関連する実験動画

    Last Updated: Feb 13, 2026

    RNA Secondary Structure Prediction Using High-throughput SHAPE
    13:42

    RNA Secondary Structure Prediction Using High-throughput SHAPE

    Published on: May 31, 2013

    32.3K
    A Nonsequencing Approach for the Rapid Detection of RNA Editing
    08:50

    A Nonsequencing Approach for the Rapid Detection of RNA Editing

    Published on: April 21, 2022

    3.0K
    RNA Catalyst as a Reporter for Screening Drugs against RNA Editing in Trypanosomes
    09:19

    RNA Catalyst as a Reporter for Screening Drugs against RNA Editing in Trypanosomes

    Published on: July 22, 2014

    8.8K
    • A dar E ditは,複数の組織コンテキストにおけるシーケンスのみCNN,トランスフォーマー,RNA言語モデルを一貫して上回りました.
    • ヒト組織データを組み合わせて,高い差別性能 (AUROC/AUPRC = 0.96; F1 ≈ 0.90) を達成しました.
    • グラフ表現の進化的に遠い非アルー種への成功移転性を実証し,保存されたADAR認識原理を明らかにしました.

    結論:

    • A dar E ditは,A-to-I RNA編集部位を予測するための強力な,構造意識のアプローチを提供します.
    • この発見は,ADAR基板認識におけるdsRNA構造の重要性を強調し,種間において原則が保たれている.
    • モデルの注意プロファイルと変異変異分析は,生化学的制約とRNA編集に対する長期的な構造的影響についての洞察を提供します.