Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Cell Diversity01:13

Cell Diversity

5.2K
The concept of a cell started with microscopic observations of dead cork tissue by Robert Hooke in 1665. Hooke coined the term "cell" based on the resemblance of the small subdivisions in the cork to the rooms that monks inhabited, called cells. About ten years later, Antonie van Leeuwenhoek became the first person to observe the living and moving cells under a microscope. In the century that followed, the theory that cells represented the basic unit of life developed.
Multicellular...
5.2K
Higher Mental Functions of Brain: Learning and Memory01:26

Higher Mental Functions of Brain: Learning and Memory

2.1K
Memory is one of the most vital higher mental functions of the brain. Memory is closely related to learning because it enables us to retain information and experiences from our past to use them in our present life. It also helps us to remember facts, events, and skills, such as riding a bike or swimming. There are two types of memory — declarative memory, which involves memorizing facts or events, and procedural memory, which enables us to remember how to do something like writing or...
2.1K
Diversity in Cell Signaling Responses01:22

Diversity in Cell Signaling Responses

8.0K
The physiological function of a cell and cellular communication are outcomes of a range of extrinsic signals, intracellular signaling pathways, and cellular responses. No two cell types express the same repertoire of signaling components. Receptors are highly selective for their cognate ligands, but once activated, they can alter multiple cellular processes such as DNA transcription, protein synthesis, and metabolic activity. 
Graded and Abrupt Responses
Some signaling systems generate...
8.0K
Cardiac Output II: Effect of Stroke Volume on Cardiac Output01:22

Cardiac Output II: Effect of Stroke Volume on Cardiac Output

3.5K
Cardiac output (CO), the amount of blood the heart pumps per minute, is a parameter in cardiovascular physiology determined by stroke volume and heart rate. Stroke volume, the amount of blood pushed from one of the ventricles per heartbeat, is influenced by preload, afterload, and contractility.
Preload
Preload refers to the initial elongation of the cardiac myocytes before contraction and is related to the volume of blood filling the heart at the end of diastole, or end-diastolic volume. The...
3.5K
Cardiac Output I:Effect of Heart Rate on Cardiac Output01:19

Cardiac Output I:Effect of Heart Rate on Cardiac Output

2.8K
Cardiac Output
Cardiac output (CO) refers to the total amount of blood ejected by one of the ventricles in liters per minute (L/min). In a resting adult, CO ranges from 5 to 6 L/min, adjusting according to the body's metabolic requirements.
Effect of Heart Rate on Cardiac Output
Cardiac output adapts to metabolic demands during stress, physical activity, or illness. The autonomic nervous system regulates heart rate via the sinoatrial node. The parasympathetic nervous system decreases heart...
2.8K
Exercise and Cardiac Output01:17

Exercise and Cardiac Output

2.0K
Regular physical activity is essential for maintaining cardiovascular health, with aerobic exercises being particularly effective. According to the American Heart Association, 150 minutes of moderate to intense aerobic exercise per week is recommended for a healthy heart. Aerobic activities may include brisk walking, running, bicycling, cross-country skiing, and swimming, ideally performed three to five times per week.
Sustained exercise increases the muscles' oxygen demand, which can be...
2.0K

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Inflammatory genital strain of Chlamydia trachomatis elicits a Th17 immune response.

Journal of immunology (Baltimore, Md. : 1950)·2026
Same author

Mechanosensing by T cells promotes a tissue-resident memory transcriptional program.

Nature immunology·2026
Same author

Functions and features of circulating memory T cells.

Immunity·2026
Same author

Bone marrow and splenic immune composition is unperturbed by short-term exposure to bedding from pet store mice.

ImmunoHorizons·2026
Same author

STEVE: Single-cell Transcriptomics Expression Visualization and Evaluation.

bioRxiv : the preprint server for biology·2026
Same author

Krüppel-like factors 2 and 3 regulate T cell exhaustion by directing T cell residency and migration.

Immunity·2026

関連する実験動画

Updated: Feb 13, 2026

Measuring Mitochondrial Function of Naïve and Effector CD8 T Cells
06:07

Measuring Mitochondrial Function of Naïve and Effector CD8 T Cells

Published on: March 28, 2025

1.2K

多種多様な微生物への曝露は,CD8+T細胞エフェクターメモリ・アウトプットと機能を強化する.

Claire E Thefaine, Erin D Lucas, Katharine E Block

    bioRxiv : the preprint server for biology
    |February 12, 2026
    PubMed
    まとめ

    標準化微生物被曝 (NME) のマウスは,より人間に似た免疫系を示しています. NMEマウスは,特異病原体フリー (SPF) のマウスと比較して,病原体のクリアランスを改善する,強化されたT細胞応答を示します.

    さらに関連する動画

    Electroporation of Functional Bacterial Effectors into Mammalian Cells
    08:39

    Electroporation of Functional Bacterial Effectors into Mammalian Cells

    Published on: January 19, 2015

    10.5K
    Imaging Effector Memory T cells in the Ear After Induction of Adoptive DTH
    09:59

    Imaging Effector Memory T cells in the Ear After Induction of Adoptive DTH

    Published on: August 14, 2008

    10.7K

    関連する実験動画

    Last Updated: Feb 13, 2026

    Measuring Mitochondrial Function of Naïve and Effector CD8 T Cells
    06:07

    Measuring Mitochondrial Function of Naïve and Effector CD8 T Cells

    Published on: March 28, 2025

    1.2K
    Electroporation of Functional Bacterial Effectors into Mammalian Cells
    08:39

    Electroporation of Functional Bacterial Effectors into Mammalian Cells

    Published on: January 19, 2015

    10.5K
    Imaging Effector Memory T cells in the Ear After Induction of Adoptive DTH
    09:59

    Imaging Effector Memory T cells in the Ear After Induction of Adoptive DTH

    Published on: August 14, 2008

    10.7K

    科学分野:

    • 免疫学 免疫学とは
    • マイクロバイオーム研究
    • 比較免疫学 比較免疫学について

    背景:

    • 特定病原体フリー (SPF) のマウスは,ヒトと異なる免疫系を持っています.
    • 標準化微生物曝露 (NME) マウスは,人間にとってより関連するモデルを提供します.
    • NMEマウスのT細胞区間の変異は十分に理解されていません.

    研究 の 目的:

    • NMEのT細胞の景観とSPFマウスの景観を比較するために.
    • ウイルス感染症 (LCMV) の初期および後のT細胞応答を調査する.
    • NMEとSPFマウスの間で異なる特定のT細胞集団を特定するために.

    主な方法:

    • immgenTデータセットをT細胞プロファイリングに活用した.
    • NMEとSPFマウスのT細胞集団を比較した.
    • リンパ球性膜炎ウイルス (LCMV) 感染前のおよび後のT細胞応答を分析した.

    主要な成果:

    • NMEマウスは,T細胞の風景が活性化されたエフェクタ細胞にシフトしたことを示した.
    • NMEマウスは,SPFマウスと比較して,病原体クリアランスの改善を示した.
    • CD8+ KLRG1+ T細胞は,形成と変換が増加したため,NMEマウスで有意に拡大しました.

    結論:

    • NMEマウスは,SPFマウスよりも多様性の高いT細胞区画を持っています.
    • NMEマウスの拡大したCD8+KLRG1+T細胞群は,エフェクタ機能の強化に寄与する.
    • NMEマウスは,ヒトに関連するT細胞免疫を研究するための貴重なモデルとして機能します.