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Updated: Feb 13, 2026

Live Cell Imaging of the TGF- β/Smad3 Signaling Pathway In Vitro and In Vivo Using an Adenovirus Reporter System
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Live Cell Imaging of the TGF- β/Smad3 Signaling Pathway In Vitro and In Vivo Using an Adenovirus Reporter System

Published on: July 30, 2018

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ソタテレセプトは,BMPR2/TGF-β-HIF-1αシグナル伝達経路を再プログラムすることによって,SIN3a欠乏によるPAHを逆転させます

Katherine Jankowski, Anurupa Ghosh, Maria T Ochoa

    bioRxiv : the preprint server for biology
    |February 12, 2026
    PubMed
    まとめ

    スイッチインデペンデント3a (SIN3a) 損失は,BMPR2シグナリングを妨害することによって,肺動脈高血圧 (PAH) を加速します. ソタテレセプト治療はPAHを逆転させ,SIN3aとBMPR2の発現を回復し,SIN3aを治療標的として強調します.

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