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Updated: Feb 13, 2026

Quantitative PCR-based Assay to Measure Sonic Hedgehog Signaling in Cellular Model of Ciliogenesis
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Quantitative PCR-based Assay to Measure Sonic Hedgehog Signaling in Cellular Model of Ciliogenesis

Published on: January 31, 2025

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トライソミー21は,ソニック・ヘッジホッグのシグナル伝達タンパク質のシリアル部位を変化させます

Wolfgang E Schleicher, Bailey L McCurdy, Cayla E Jewett

    bioRxiv : the preprint server for biology
    |February 12, 2026
    PubMed
    まとめ

    ダウン症候群 (トリソミア21) は,プライマリーシリアのスムージング (SMO) タンパク質を減少させることで,ソニック・ヘッジホッグ (SHH) のシグナル伝達を損なう. シリアの成熟が遅れていることが,SHH経路の機能に影響を及ぼすこの欠陥を説明する可能性がある.

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