関連する実験動画

Updated: Feb 13, 2026

Author Spotlight: Decoding Metastasis-to-Metastasis Seeding Using a New In Vivo Technique for Tracking Breast Cancer Spread
05:23

Author Spotlight: Decoding Metastasis-to-Metastasis Seeding Using a New In Vivo Technique for Tracking Breast Cancer Spread

Published on: July 7, 2023

1.6K

染色体構造と物理的収縮は,フェノタイプスイッチングとがん細胞の拡散に協力する

Pietro Berico, Cody Dunton, Luay Almassalha

    bioRxiv : the preprint server for biology
    |February 12, 2026
    PubMed
    まとめ

    転移性メラノーマ細胞は,機械的圧力とヘテロクロマチンの損失によって引き起こされる表遺伝的および構造的な核変化を経験します. これらの適応は,侵襲性と転移の可能性を高め,新しい治療目標を提供します.

    さらに関連する動画

    Slide Preparation Method to Preserve Three-dimensional Chromatin Architecture of Testicular Germ Cells07:34

    Slide Preparation Method to Preserve Three-dimensional Chromatin Architecture of Testicular Germ Cells

    Published on: January 10, 2014

    7.9K
    A Multimodal Imaging Framework to Advance Phenotyping of Living Label-free Breast Cancer Cells10:37

    A Multimodal Imaging Framework to Advance Phenotyping of Living Label-free Breast Cancer Cells

    Published on: August 22, 2025

    1.3K

    関連する概念動画

    Inheritance of Chromatin Structures03:17

    Inheritance of Chromatin Structures

    Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying...
    7.6K
    Cooperative Allosteric Transitions01:58

    Cooperative Allosteric Transitions

    Cooperative allosteric transitions can occur in multimeric proteins, where each subunit of the protein has its own ligand-binding site. When a ligand binds to any of these subunits, it triggers a conformational change that affects the binding sites in the other subunits; this can change the affinity of the other sites for their respective ligands. The ability of the protein to change the shape of its binding site is attributed to the presence of a mix of flexible and stable segments in the...
    8.9K
    Cooperative Allosteric Transitions01:58

    Cooperative Allosteric Transitions

    3.1K
    Cooperative Allosteric Transitions01:58

    Cooperative Allosteric Transitions

    2.7K
    Cooperative Binding of Transcription Regulators02:13

    Cooperative Binding of Transcription Regulators

    Transcriptional regulators bind to specific cis-regulatory sequences in the DNA to regulate gene transcription. These cis-regulatory sequences are very short, usually less than ten nucleotide pairs in length. The short length means that there is a high probability of the exact same sequence randomly occurring throughout the genome.  Since regulators can also bind to groups of similar sequences, this further increases the chances of random binding. Transcriptional regulators form...
    7.4K
    Chromatin Position Affects Gene Expression02:35

    Chromatin Position Affects Gene Expression

    Chromatin is the massive complex of DNA and proteins packaged inside the nucleus. The complexity of chromatin folding and how it is packaged inside the nucleus greatly influences  access to genetic information. Generally, the nucleus' periphery is considered transcriptionally repressive, while the cell's interior is considered a transcriptionally active area. 
    Topologically Associated Domains (TADs)
    The 3-dimensional positioning of chromatin in the nucleus influences the...
    24.9K