Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Animal Mitochondrial Genetics02:59

Animal Mitochondrial Genetics

9.3K
Among all the organelles in an animal cell, only mitochondria have their own independent genomes. Animal mitochondrial DNA is a double-stranded, closed-circular molecule with around 20,000 base pairs. Mitochondrial DNA is unique in that one of its two strands, the heavy, or H, -strand is guanine rich, whereas the complementary strand is cytosine rich and called the light, or L, -strand. Compared to nuclear DNA, mitochondrial DNA has a very low percentage of non-coding regions and is marked by...
9.3K
Comparing Mitochondrial, Chloroplast, and Prokaryotic Genomes02:16

Comparing Mitochondrial, Chloroplast, and Prokaryotic Genomes

17.0K
The present-day mitochondrial and chloroplast genomes have retained some of the characteristics of their ancestral prokaryotes and also have acquired new attributes during their evolution within eukaryotic cells. Like prokaryotic genomes, mitochondrial and chloroplast genomes neither bind with histone-like proteins nor show complex packaging into chromosome-like structures, as observed in eukaryotes. Unlike mitotic cell divisions observed in eukaryotic cells, mitochondria and chloroplasts...
17.0K
Space Trusses01:25

Space Trusses

1.3K
A space truss is a three-dimensional counterpart of a planar truss. These structures consist of members connected at their ends, often utilizing ball-and-socket joints to create a stable and versatile framework. The space truss is widely used in various construction projects due to its adaptability and capacity to withstand complex loads.
At the core of a space truss lies the fundamental unit known as the tetrahedron. This structure is composed of six members that form a three-dimensional shape...
1.3K
State Space Representation01:27

State Space Representation

610
The frequency-domain technique, commonly used in analyzing and designing feedback control systems, is effective for linear, time-invariant systems. However, it falls short when dealing with nonlinear, time-varying, and multiple-input multiple-output systems. The time-domain or state-space approach addresses these limitations by utilizing state variables to construct simultaneous, first-order differential equations, known as state equations, for an nth-order system.
Consider an RLC circuit, a...
610
Export of Mitochondrial and Chloroplast Genes02:19

Export of Mitochondrial and Chloroplast Genes

4.2K
A eukaryotic cell can have up to three different types of genetic systems: nuclear, mitochondrial, and chloroplast. During evolution, organelles have exported many genes to the nucleus; this transfer is still ongoing in some plant species. Approximately 18% of the Arabidopsis thaliana nuclear genome is thought to be derived from the chloroplast’s cyanobacterial ancestor, and around 75% of the yeast genome derived from the mitochondria’s bacterial ancestor. This export has occurred...
4.2K
Space Trusses: Problem Solving01:29

Space Trusses: Problem Solving

916
A space truss is a three-dimensional counterpart of a planar truss. These structures consist of members connected at their ends, often utilizing ball-and-socket joints to create a stable and versatile framework. Due to its adaptability and capacity to withstand complex loads, the space truss is widely used in various construction projects.
Consider a tripod consisting of a tetrahedral space truss with a ball-and-socket joint at C. Suppose the height and lengths of the horizontal and vertical...
916

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Mpf1 affects the dual distribution of tail-anchored proteins between mitochondria and peroxisomes.

EMBO reports·2025
Same author

Sub-organellar mitochondrial hydrogen peroxide observed using a SNAP tag targeted coumarin-based fluorescent reporter.

Redox biology·2025
Same author

Analysis of targeting signals for mitochondrial intermembrane space import.

Methods in enzymology·2024
Same author

The C-terminus of the prototypical M2 muscarinic receptor localizes to the mitochondria and regulates cell respiration under stress conditions.

PLoS biology·2024
Same author

The derlin Dfm1 couples retrotranslocation of a folded protein domain to its proteasomal degradation.

The Journal of cell biology·2024
Same author

MIMAS is a new giant multifunctional player in the mitochondrial megacomplex playground.

Cell reports·2024

関連する実験動画

Updated: Feb 13, 2026

Quantifying Intermembrane Distances with Serial Image Dilations
07:45

Quantifying Intermembrane Distances with Serial Image Dilations

Published on: September 28, 2018

6.8K

ミトコンドリアの膜間空間の中と外へ.

Fara van der Schans1, Kostas Tokatlidis1, Daniela G Vitali1

  • 1School of Molecular Biosciences, University of Glasgow, Glasgow, UK.

Protein science : a publication of the Protein Society
|February 12, 2026
PubMed
まとめ

ミトコンドリア膜間空間 (IMS) は,核にコードされたタンパク質の分類に不可欠です. タンパク質の折りたたみと分解を監視し,ミトコンドリアのプロテオスタシスと機能を維持します.

科学分野:

  • ミトコンドリア生物学
  • 細胞のプロテオスタシス
  • オーガネルの生体生成

背景:

  • ミトコンドリアは,外膜 (OMM),内膜 (IMM),膜間空間 (IMS) およびマトリックスという異なるコンパートメントを有しています.
  • ミトコンドリアにはゲノムがあるが,ほとんどのミトコンドリアタンパク質 (99%) は核でコードされ,輸入されている.
  • IMSは,ミトコンドリアタンパク質の輸入と品質管理のための重要なチェックポイントとして機能します.

研究 の 目的:

  • ミトコンドリアのIMSにタンパク質を分類するメカニズムを見直す.
  • ミトコンドリアのプロテオスタシスを調節するIMSの役割について議論します.
  • 全体的なミトコンドリア機能に対するIMSの貢献を強調する.

主な方法:

  • ミトコンドリアタンパク質の輸入と分類経路に関する文献レビュー.
  • タンパク質の品質管理と分解におけるIMSの役割の分析.
  • 細胞経路におけるIMS機能に関する現在の理解の統合.

主要な成果:

  • IMSは,ミトコンドリアタンパク質のモニタリングのための戦略的なハブです.
  • 核でコードされたIMSタンパク質は,酸化還元調節,カルシウムシグナル伝達,アポトーシス,低酸素反応などの細胞プロセスに不可欠です.
キーワード:
ミア40 ミア40 ミア40 ミア40膜間空間とは,膜間空間である.酸化性折り畳みによる折り畳みプロテオスタシスプロテオスタシス

さらに関連する動画

Genotyping Single Nucleotide Polymorphisms in the Mitochondrial Genome by Pyrosequencing
07:24

Genotyping Single Nucleotide Polymorphisms in the Mitochondrial Genome by Pyrosequencing

Published on: February 10, 2023

2.0K
Development of a Mobile Mitochondrial Physiology Laboratory for Measuring Mitochondrial Energetics in the Field
08:54

Development of a Mobile Mitochondrial Physiology Laboratory for Measuring Mitochondrial Energetics in the Field

Published on: August 27, 2021

1.8K

関連する実験動画

Last Updated: Feb 13, 2026

Quantifying Intermembrane Distances with Serial Image Dilations
07:45

Quantifying Intermembrane Distances with Serial Image Dilations

Published on: September 28, 2018

6.8K
Genotyping Single Nucleotide Polymorphisms in the Mitochondrial Genome by Pyrosequencing
07:24

Genotyping Single Nucleotide Polymorphisms in the Mitochondrial Genome by Pyrosequencing

Published on: February 10, 2023

2.0K
Development of a Mobile Mitochondrial Physiology Laboratory for Measuring Mitochondrial Energetics in the Field
08:54

Development of a Mobile Mitochondrial Physiology Laboratory for Measuring Mitochondrial Energetics in the Field

Published on: August 27, 2021

1.8K
  • IMSを通過するタンパク質の通過は,標的と折り畳み状態の注意深い監視を伴う.

    • 結論:

    • IMSは,ミトコンドリアのプロテオスタシスの維持に中心的な役割を果たします.
    • IMSへのタンパク質分類を制御するメカニズムは,臓器細胞の機能にとって極めて重要です.
    • IMSの適切な機能は,細胞の健康とストレスへの反応に不可欠です.