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Updated: Feb 13, 2026

An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells
09:41

An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells

Published on: July 15, 2015

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EZH2抑制は,脳芽細胞依存経路を通じて,多発性骨髄腫における免疫調節薬剤耐性を克服する

Yigen Li1, Amy Wilson1, Yakinthi Chrisochoidou1

  • 1The Institute of Cancer Research.

Haematologica
|February 12, 2026
PubMed
まとめ

EZH2阻害剤とIMiD/CELMoDを併用すると,IRF4発現を低下させ,細胞死亡を誘発することで,多発性骨髄腫における一次抵抗を克服します. この戦略は,治療結果を改善するための主要な経路をターゲットにしています.

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