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妊娠中のストレスと流産率の予測研究
Amelia K Wesselink1, Ruth J Geller1, Sharonda M Lovett1
1Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA.
Human reproduction (Oxford, England)
|February 12, 2026
まとめ
妊娠前期ではなく,妊娠初期に感じるストレスは,流産のリスクが高いことと関連しています. 妊娠初期にストレスを軽減するための介入は,妊娠中絶を予防するのに役立ちます.
科学分野:
- 生殖器保健は,生殖器の健康についてです.
- 妊娠中の心理社会的要因
- перинатаル流行病学について
背景:
- 以前の研究では,ストレスと流産のリスクとの関連が示唆されていたが,研究は往復的な設計や職業上のストレスに焦点を当てるような制限をしばしば抱えていた.
- また,先行研究で流産の確認が不十分であったことも,ストレスと流産の関係に関する明確な理解を妨げている.
研究 の 目的:
- 妊娠前期および妊娠初期におけるストレスと流産の発生率との関連を調査する.
主な方法:
- 21歳から45歳の参加者が妊娠を試みた前向きなコホート研究 (Pregnancy Study Online - PRESTO)
- 妊娠前期および妊娠初期における認知ストレススケール (PSS-10) を用いて測定された認知ストレス.
- PSS-10スコアに基づいて流産発生率を分析するために使用されたコックス比例リスク回帰モデル,混同因子調整.
主要な成果:
- 妊娠前のストレス (女性または男性パートナーの場合) と流産の発生率との間に有意な関連性が見つかりませんでした.
- 妊娠初期 (妊娠5-8週) のストレスを感じることは,妊娠中絶の発生率が高いことと強く関連していました.
- 妊娠初期ストレスと流産リスクとの関連は,PSS-10スコアが高くなり,妊娠第7週頃にピークに達すると増加しました.
結論:
- 妊娠初期におけるストレス感は,妊娠前期ではないが,流産のリスクの増加と関連している.
- 発見は,妊娠初期における流産予防のためのストレス軽減介入の潜在的な利点を示唆しています.
- ランダム化対照試験によるさらなる確認は,逆因果関係や測定されていない混同などの潜在的な制限のために正当化されています.
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