不活性炎症性腸疾患の患者における持続的な腹痛:臨床的な謎
Alessandra Dell'Era1, Elisabetta Antonelli2, Fotios S Fousekis3
1Gastroenterology Unit, Department of Biomedical and Clinical Sciences, Luigi Sacco Hospital, University of Milan, Milan, Italy.
不活性炎症性腸疾患の患者は,継続的な炎症ではなく,腸-脳軸の不調による持続的な腹痛を経験することが多い. このレビューは,多因性の原因を探求し,治療に対する生体心理社会的アプローチを提唱しています.
科学分野:
- 胃腸内科 胃腸内科
- 神経胃腸内科 神経胃腸内科
- 免疫学 免疫学とは
背景:
- 炎症性腸疾患 (IBD) は,腸のホメオスタシスを破壊し,活発な炎症が解消した後でも,持続的な腹部症状を引き起こす可能性があります.
- IBD患者の有意な割合は,寛解中に刺激性腸症候群 (IBS) に似た症状を報告しています.
研究 の 目的:
- IBD寛解における持続的な腹痛に関する文献をレビューし,批判的に検討する.
- これらの症状の根底にある多要素的病理生理学を探求する.
- 総合的な診断と治療アプローチの必要性を強調する.
主な方法:
- 文献レビューおよび関連する研究の批判的検討.
主要な成果:
- 持続的な症状は,生活の質を著しく低下させ,しばしば障害となる.
- これらの症状の根本的な原因を特定することは困難です.
結論:
- 新興の証拠は,内臓過敏症,腸内神経系の変化,中枢感受性,腸-脳軸不調,および心理社会的要因を含む複雑な相互作用を指しています.
- これらの要因は,進行中の粘膜炎ではなく,IBD寛解の痛みに寄与します.
- 総合的な生体心理社会的アプローチは,診断と治療において極めて重要です.
さらに関連する動画
08:27Dynamic Adhesion Assay for the Functional Analysis of Anti-adhesion Therapies in Inflammatory Bowel Disease
Published on: September 20, 2018
07:10Author Spotlight: Development and Application of a Canine IBD Gut-on-a-Chip Model for 3D Intestinal Morphogenesis Studies
Published on: February 9, 2024
関連する概念動画
Inflammatory Bowel Disease II: Crohn's Disease
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory Bowel Disease I: Ulcerative Colitis
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory Bowel Disease V: Surgical Management
Here are some common surgical interventions for IBD:
Inflammatory Bowel Disease IV: Pharmacological Management
Pharmacologic...
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
