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Updated: Feb 13, 2026

Green Fluorescent Protein-based Expression Screening of Membrane Proteins in Escherichia coli
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Green Fluorescent Protein-based Expression Screening of Membrane Proteins in Escherichia coli

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タンパク質対タンパク質相互作用の自然産物調節剤:包括的なレビュー

Emadeldin M Kamel1, Ahmed A Allam2, Hassan A Rudayni2

  • 1Chemistry Department, Faculty of Science, Beni-Suef University, Beni-Suef, Egypt.

Phytochemical analysis : PCA
|February 12, 2026
PubMed
まとめ

天然製品は,タンパク質-タンパク質相互作用 (PPI) を効果的に調節し,がんなどの疾患に対する多様な治療効果を提供します. このレビューは,主要なPPIをターゲットとする天然化合物を詳細に説明し,薬物開発におけるその可能性を強調しています.

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Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a...
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A protein's shape is critical to its function. For example, an enzyme...
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