関連する実験動画

Updated: Feb 13, 2026

CRISPR/Cas9-Mediated Highly Efficient Gene Targeting in Embryonic Stem Cells for Developing Gene-Manipulated Mouse Models
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Published on: August 24, 2022

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熱媒介によるIR-LEGOによる遺伝子発現の操作は,ドロソフィラの発達中の生殖器に作用する

Moe Onuma1, Tatsuyuki Kumagai1, Kentaro Hayashi2

  • 1Department of Biological Sciences, Tokyo Metropolitan University, Hachioji 192-0397, Japan.

G3 (Bethesda, Md.)
|February 12, 2026
PubMed
まとめ

研究者は,赤外線レーザー誘発遺伝子オペレーターシステム (IR-LEGO) を使用して,ドロソフィラの遺伝子発現を正確に制御しました. この方法は,外部生殖器の発達における標的型遺伝子ノックダウンを可能にし,急速に進化する解剖学的構造の研究を支援します.

キーワード:
ドロソフィラ (Drosophila) とは赤外線レーザー誘発遺伝子オペレーターシステム (IR-LEGO)RNAi (RNAi) とは生殖器は,生殖器である熱ショックによる熱ショックです.

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What is Gene Expression?01:42

What is Gene Expression?

Overview
Gene expression is the process in which DNA directs the synthesis of functional products, that is, proteins. Cells can regulate gene expression at various stages. It allows organisms to generate different cell types and enables cells to adapt to internal and external factors.
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A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is comprised  of nucleotides and proteins are comprised of amino acids, a mediator is required to convert the information encoded in DNA into proteins. This mediator is the messenger RNA (mRNA). mRNA copies the blueprint from DNA by a process called transcription. In eukaryotes, transcription occurs in the nucleus by complementary base-pairing with the DNA template. The mRNA is then...
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Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
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Chromatin is the massive complex of DNA and proteins packaged inside the nucleus. The complexity of chromatin folding and how it is packaged inside the nucleus greatly influences  access to genetic information. Generally, the nucleus' periphery is considered transcriptionally repressive, while the cell's interior is considered a transcriptionally active area. 
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The 3-dimensional positioning of chromatin in the nucleus influences the...
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The structure and stability of mRNA molecules regulates gene expression, as mRNAs are a key step in the pathway from gene to protein. In eukaryotes, the half-life of mRNA varies from a few minutes up to several days. mRNA stability is essential in growth and development. The absence of the proteins regulating its stability, such as tristetraprolin in mice, can cause systemic issues, including bone marrow overgrowth, inflammation, and autoimmunity.
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