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Updated: Feb 13, 2026

Author Spotlight: Studying Drug Impacts on Brain Signals Using Dual LFP Recording Protocol in Mice
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フェニルケトンウリアは,マウスの遺伝的背景に関係なく,前頭前皮質の全ゲノム表現プロフィールを変化させます

Elena Fiori1,2, Serafina Manila Guzzo2, Luisa Lo Iacono3,4

  • 1Technopole Foundation, 00185 Rome, Italy.

Cells
|February 12, 2026
PubMed
まとめ

フェニルケトンウリア (PKU) のマウスモデルでは,脳内のタンパク質翻訳とミエリン化遺伝子発現が変化している. この研究は,マウスにおけるPKU誘発の作業記憶の欠陥を明らかにし,PKU患者における実行機能不全の洞察を提供している.

キーワード:
HPAのレジリエンスと脆弱性注意力,記憶力,そして注意力.フェニルケトノヌリア現象前頭前皮質前頭前皮質トランスクリプトーム transcriptome

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