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Updated: Feb 13, 2026

Examining BCL-2 Family Function with Large Unilamellar Vesicles
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WWOX誘導は,ストレス反応に対するリソソーム経路を通じたBcl-XLとMcl-1の劣化を促進する

Yu-Han Su1, Wei Chiang2, Yi-Yu Wang1

  • 1Department of Medical Laboratory Science and Biotechnology, College of Medicine, National Cheng Kung University, Tainan 701401, Taiwan.

Cells
|February 12, 2026
PubMed
まとめ

ストレスはWWOX遺伝子の発現を増加させ,細胞死経路に影響を与えます. WWOXは,リソソーム経由でBcl-XLおよびMcl-1タンパク質の分解を促進し,酸化ストレスを悪化させます.

キーワード:
Bcl-2ファミリーBcl-2ファミリーリンソソームはリンソソームである.酸化ストレスによるストレスです.タンパク質の分解 タンパク質の分解腫瘍サプレッサー 腫瘍サプレッサー

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