関連する実験動画

Updated: Feb 13, 2026

A High Resolution Method to Monitor Phosphorylation-dependent Activation of IRF3
11:44

A High Resolution Method to Monitor Phosphorylation-dependent Activation of IRF3

Published on: January 24, 2016

12.5K

PCIF1は,IRF3の活性化をメチルトランスフェラーゼから独立した方法で阻害することによって,タイプIインターフェロン誘導を弱める

Ryoya Kano1, Chihiro Oyama1, Chihiro Ikeda1

  • 1Department of Gene Regulation, Faculty of Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.

Cells
|February 12, 2026
PubMed
まとめ

PCIF1は,重要な抗ウイルス免疫経路であるタイプIインターフェロン (IFN) 誘導を否定的に調節する. PCIF1のこの新しいメチルトランスファーゼ独立機能は,炎症性疾患に対する治療的可能性を秘めています.

キーワード:
IRF3 IRF3 IRF3 IRF3 IRF3 IRF3PCIF1 (PCIF1) について抗ウイルス反応による抗ウイルス反応.生まれながらの免疫力m6Am でした.mRNAの改変により発生する.トランスクリプション規制I型インターフェロンです.

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