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発酵紅人参は,老化に関連したインスリンホメオスタシスとマウスの腸内微生物のバランスを回復します
Da-Yeon Lee1, Jing Liu2, Gopal Lamichhane1
1Department of Nutritional Sciences, Oklahoma State University, Stillwater, OK 74078, USA.
Biology
|February 12, 2026
まとめ
発酵赤 ginseng (FRG) 補給は,高齢マウスの年齢に関連するインスリン抵抗性および腸内機能不良を改善しました. FRGはインスリンシグナル伝達を強化し,有益な腸内細菌を促進し,抗老化ダイエットサプリメントとしての可能性を示唆しています.
科学分野:
- ゲロントロジーはゲロントロジーの学科です.
- メタボリック・ヘルス (代謝の健康)
- マイクロバイオーム研究
背景:
- 生物学的老化は肝臓と腸の通信を阻害し,インスリン抵抗性,2型糖尿病,腸内機能障害を引き起こす.
- ジンゼノシドに富んだ発酵紅人参 (FRG) は,抗炎症および抗糖尿病特性を有しています.
- FRGが生物学的老化および年齢関連の代謝機能障害に及ぼす影響は,まだほとんど研究されていない.
研究 の 目的:
- 高齢の雄マウスの年齢に関連するインスリンホメオスタシス障害と腸内機能不全の改善におけるFRGの健康上の利点を調査する.
- インスリンシグナル伝達と炎症に関与する重要な分子経路に対するFRGの影響を評価する.
- 老齢マウスの腸内微生物群組成に対するFRGの影響を分析する.
主な方法:
- 高齢のオスのマウス (19ヶ月) は,通常のチョウダイエット (NCD) または14週間にわたってFRG (300 mg/kg) を補充したNCDを摂取しました.
- インスリンホメオスタシスは,肝臓タンパク質キナーゼB (AKT) とプロリンに富んだAKT基板の40 kDa (PRAS40) の活性化を測定することによって評価されました.
- 肝炎は,炎症性サイトカインのmRNA発現と組織学的分析によって評価されました.
- 腸内微生物群の組成は16S rRNA配列を用いて分析され,細菌分類の変化を決定した.
主要な成果:
- FRGのサプリメントは,肝臓のAKTとPRAS40.0を活性化することによって,インスリンホメオスタシスを著しく改善しました.
- FRGの投与は,炎症誘発性サイトカインの発現を抑制し,肝臓内の炎症性浸透を減少させた.
- FRGは腸内微生物群を調節し,Firmicutes/Bacteroidetesの比率を下げ,MuribaculaceaeやParasutterellaのような有益な属を豊かにしました.
- FRGは,ErysipelotrichaceaeとDubosiellaを含む有害な属の豊富さを減少させました.
結論:
- 発酵紅人参は,高齢化に起因する代謝機能障害との闘いにおいて,健康に有意義な利点を示しています.
- FRGはインスリンホメオスタシスを改善し,高齢マウスの肝炎を軽減します.
- FRGは腸内微生物の組成をポジティブに調節し,年齢に関連する代謝失調の管理のためのアンチエイジングの栄養補助食品としての可能性を示唆しています.
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