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Updated: Feb 13, 2026

Studying Interactions between Myeloid Cells and CAR T Cells In Vitro and In Vivo
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Studying Interactions between Myeloid Cells and CAR T Cells In Vitro and In Vivo

Published on: July 25, 2025

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不変のNKG2D-CAR T細胞機能は,骨肉肉腫における低酸素下で,インビトロで

Laura Hidalgo1,2,3, Patricia Garcia-Rodriguez4,5, Isabel Cubillo4

  • 11Biomedical Innovation Unit, Centro de Investigaciones Energéticas Medioambientales y Tecnológicas (CIEMAT), 28040, Madrid, Spain. laura.hidalgo@ciemat.es.

Cancer immunology, immunotherapy : CII
|February 12, 2026
PubMed
まとめ

低酸素症は,小児性骨肉腫 (OS) モデルにおけるNKG2Dキメリック抗原受容体 (CAR) T細胞機能を損なわない. これらの発見は,ヒポキシアだけでは,腫瘍の微小環境におけるCAR T細胞の有効性を阻害するという考えに異議を唱える.

キーワード:
(CAR) キメリック抗原受容体:NKG2DD(OS) オステオサルコーマ低酸素症とは免疫療法による免疫療法です.

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