甲状腺/副甲状腺機能とフッ素:ミトコンドリアDNAとSODの遺伝子変異の役割
Qing Sun1, Zichen Feng1, Long Sun2
1Department of Occupational and Environmental Health, School of Public Health, Zhengzhou University, Zhengzhou, 450001, Henan, China.
Journal of endocrinological investigation
|February 12, 2026
まとめ
子どもにおける過度のフッ化物曝露は,甲状腺の変化と甲状腺側ホルモンの減少と関連しており,ミトコンドリアDNA複製数は女の子において仲介的な役割を果たしている. SOD2とSOD3の遺伝的変異は,これらのフッ素誘発の甲状腺効果に影響を与える可能性があります.
科学分野:
- 環境衛生 環境衛生 環境衛生
- エンドクリノロジー エンドクリノロジー
- 毒理学 毒理学 毒理学
背景:
- 新興の証拠は,過度のフッ化物曝露が,酸化ストレスとミトコンドリア機能不全を含む甲状腺および副甲状腺機能に害を与える可能性があることを示唆しています.
- しかし,甲状腺/副甲状腺の健康に対するフッ素の影響と,酸化ストレスに関連する単一核酸多型体 (SNP) との相互作用に関する疫学的なデータは限られている.
研究 の 目的:
- 尿中のフッ化物 (UF) レベルと小児における甲状腺/副甲状腺機能の関連性を調査する.
- ミトコンドリアのDNA複製数 (mtDNA-CN) と,UFとスーパーオキシドディスミュータゼ (SOD) の間の遺伝子環境相互作用の媒介効果を検証する.
主な方法:
- 中国,トンシュウ郡のフッ化物にさらされた地域における401人の子ども (7歳から13歳) を対象とした横断的な研究.
- 尿中のフッ素濃度,甲状腺体量 (Tvol),副甲状腺ホルモン (PTH),mtDNA-CN.の分析
- 汎用多要素次元還元 (GMDR) を使用したUFとSOD2/SOD3遺伝子ポリモルフィズム間の相互作用を調査した.
主要な成果:
- UF濃度の上昇は,より大きなTvol,PTHの減少,および子供のmtDNA-CNの減少と関連していました.
- 女の子では,相対的なmtDNA-CNが部分的にUFとTvolとの関連を媒介した (33.08%の媒介).
- SOD2 (rs4880) とSOD3 (rs13306703) の特定のゲノタイプは,UFと相互作用し,TvolとPTHレベルに影響を与えました.
結論:
- 飲料水中のフッ化物への曝露は,小児における甲状腺機能の変化と関連しています.
- 減少したmtDNA-CNによって示されるミトコンドリア機能障害は,少女の甲状腺容量に対するフッ素の効果を部分的に媒介する.
- SOD2とSOD3の遺伝的変異は,フッ化物誘発の甲状腺機能不全に対する子供の感受性を変化させる可能性があります.
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