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Updated: Feb 14, 2026

Multidisciplinary Approach to Obesity Management: A Case Report
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PPARα-NFκBヘテロダイマーは,IL-6のオトクリン産生を通じて,肥満誘発のダイアストリック機能不全を媒介する

Shin-Ichi Oka1, Eun-Ah Sung1, Peiyong Zhai1

  • 1Department of Cell Biology and Molecular Medicine, Rutgers New Jersey Medical School, Newark, United States of America.

The Journal of clinical investigation
|February 12, 2026
PubMed
まとめ

肥満に起因する高レベルの自由脂肪酸 (FFAs) は,心臓細胞のIL-6を直接増加させ,下痢性機能不全を引き起こす. この経路にはPPARαとNFκBが含まれ,IL-6が肥満性心筋疾患の重要な要因であることを強調しています.

キーワード:
心臓病学 心臓病学メタボリズムはトランスクリプション トランスクリプション

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