トレースレスFcリガンド誘導アキレーション戦略による同質なDAR4ADCの1段階組立

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Updated: Feb 14, 2026

Detection of Protein S-Acylation using Acyl-Resin Assisted Capture
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Detection of Protein S-Acylation using Acyl-Resin Assisted Capture

Published on: April 10, 2020

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Yue Zeng1,2,3, Yuyu Lin4, Qi Sun4

  • 1Key Laboratory of Glyco-drug Research of Zhejiang Province, School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, China.

ChemMedChem
|February 12, 2026
PubMed
まとめ

この研究では,抗体対抗体比 (DAR) が一貫して4である均質な抗体対抗体結合体 (ADC) を生成するための新しい1段階の方法が導入されています. 最適化されたプロセスは,新しいバイオセラピーの安定性と治療可能性を向上させます.

キーワード:
DAR4は,DAR4に該当する.K248 サイト固有のADC抗腫瘍剤は抗腫瘍剤として使われています.一段階の結合法である.

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