右手と左手の熟練度試験における前頭前皮質の接続性,若年および高齢の成人の右手と左手の熟練度試験における前頭前皮質の接続性
Manjiri Kulkarni1,2,3, Peter Rassam2, Pedram Mouseli4,5
1Rehabilitation Sciences Institute, University of Toronto, Toronto, Ontario, Canada.
PloS one
|February 12, 2026
まとめ
高齢者は,特に非支配的な手を使って,手による熟練作業中に,前頭前皮質 (PFC) の機能的な接続性が変化していることを示しています. 神経活動ペアリングの増加は観察されましたが,タスク効率を改善しませんでした.
科学分野:
- 神経科学は神経科学である.
- 認知神経科学とは
- ヒューマン・モーター・コントロール
背景:
- 老化は,複雑な運動タスク中に前頭前皮質 (PFC) の活性化と接続性に影響を及ぼします.
- 手の熟能性能と関連する神経活動が,若年成人と高齢者の間で異なっています.
研究 の 目的:
- 右側と左側の9ホールのピークテスト (R9HPTとL9HPT) でPFC領域内の機能的な接続性を比較する.
- 手作業の熟練作業中にPFCの機能的接続性における年齢関連の違いを調査する.
主な方法:
- 機能的近赤外線光譜法 (fNIRS) は,PFCの8つの領域における神経活動 (酸素化されたヘモグロビン) を測定した.
- タイムシリーズ分析は,若年および高齢の成人のタイミング化されたR9HPTおよびL9HPTの間にPFC領域間の機能的接続性を評価した.
主要な成果:
- 高齢者は,若年成人と比較して,R9HPTとL9HPTの両方の完了時間が長いことを示しました.
- PFC領域内のおよびPFC領域間の機能的な接続パターンは,年齢層とグループによって異なっていた.
- 神経活動の増加 (∆O2Hb) は,特に特定のPFC領域を含む,高齢者のタスク時間が長くなることと相関しています.
結論:
- PFCの機能的な接続性は,手作業の際の若者と高齢者の間で異なります.
- 非支配的な手と高齢者は,より大きなPFC接続性を必要としますが,これはタスクの効率を向上しません.
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