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Updated: Feb 14, 2026

De Novo Generation of Somatic Stem Cells by YAP/TAZ
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PI3Kは,TAZ/YAPとmTORC1軸を調節し,これにより,連携的にターゲットにすることができます

Keith C Garcia1, Ali A Khan1, Krishnendu Ghosh1

  • 1Department of Pathology, The University of Iowa, Iowa City, United States of America.

JCI insight
|February 12, 2026
PubMed
まとめ

フォスフォノシチド3キナーゼ (PI3K) 信号伝達は,TAZ/YAP経由でサルコマの成長を誘導する. 併用療法でPI3K,TAZ/YAP-TEAD,mTORC1をターゲットにすることは,臨床前サルコマモデルにおいて,シナージ効果を示している.

キーワード:
がん がん がん がん がん細胞生物学 細胞生物学腫瘍学 腫瘍学シグナルトランスデュークション.

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