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Updated: Feb 14, 2026

A Protocol for Comprehensive Assessment of Bulbar Dysfunction in Amyotrophic Lateral Sclerosis ALS
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A Protocol for Comprehensive Assessment of Bulbar Dysfunction in Amyotrophic Lateral Sclerosis ALS

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アミオトロフィック横筋硬化症における代謝機能障害を標的とする:GLP-1受容体アゴニストの治療的可能性

Mohamed Mohsen Helal1, Nereen A Almosilhy2, Dina Essam Abo-Elnour1,3

  • 1Faculty of Medicine, Zagazig University, Zagazig, Egypt.

Amyotrophic lateral sclerosis & frontotemporal degeneration
|February 12, 2026
PubMed
まとめ

グルカゴン類ペプチド-1受容体アゴニスト (GLP-1RAs) は,代謝および神経保護効果のために,アミオトロフィック横筋硬化症 (ALS) の治療の可能性を示しています. しかし,現在の臨床データは限られており,安全性に関する懸念を提起しており,ALS患者での有効性は不明であることを示しています.

キーワード:
アミオトロフィック横筋硬化症 (ALS)エクセンディン-4 (Ex-4)グルカゴンのようなペプチド-1 (GLP-1)グルカゴンのようなペプチド-1受容体アゴニスト (GLP-1RAs)ハイパーメタボリズムメタボリック機能障害モーターニューロン疾患 (MND)神経変性疾患 (NDG) とはニューロプロテクション減量 減量 減量 減量 減量 減量 減量

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