関連する実験動画
Updated: Feb 14, 2026

05:51
A Bright NIR-II Fluorescence Probe for Vascular and Tumor Imaging
Published on: March 17, 2023
2.3K
ニトロレダクタゼで誘発されたNIR光探査機で,オートトーピック乳癌の選択的視覚化を行っています
Xiaoyu Wan1, Sisi Wang2, Pinyi Ma3
1Department of Breast Surgery, The Second Hospital of Jilin University, Changchun 130041, China.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
|February 12, 2026
まとめ
新しい近赤外線 (NIR) の光センサーであるDHM-NO2は,乳がんにおける窒素還元酵素 (NTR) 活性を効果的に視覚化しています. この探査機は,腫瘍の攻撃性および治療応答のイメージングを改善し,既存の方法の限界を克服します.
科学分野:
- バイオメディカルイメージング
- 化学生物学 化学生物学とは
- 分子腫瘍学 分子腫瘍学
背景:
- ニトロレダクトーゼ (NTR) は,乳腺腫瘍の代謝において不可欠であり,攻撃性および治療結果を示しています.
- NTR可視化のための既存の探査機は,限られた光物理的特性を有しており,正確なイメージングを妨げています.
研究 の 目的:
- 乳がんにおける窒素還元酵素 (NTR) 活性を視覚化するための,近赤外線 (NIR) 活性化可能な新型光センサーの開発.
- 短い放射波長と現在の探査機の小さなストークスシフトの限界を克服するために.
主な方法:
- DHM-OHフローロフォアとニトロベンジル認識装置を組み合わせてDHM-NO2を製造した.
- 乳がん細胞 (MCF-7) と正常細胞 (MCF-10A) を用いて試験管の性能を in vitro で評価した.
- オーソトーピック乳がんマウスモデルで探査機の活性化と腫瘍の局所化を評価した.
主要な成果:
- DHM-NO2は軽微な背景光とNTR媒介による急速な活性化を示し,DHM-OHをNIR放射 (880 nm) に放出しました.
- 探査機は高い感度 (25.6 pg/mL検出限界),選択性,およびROS/RNS干渉に対する耐性を示した.
- がん細胞を成功裏に分化し,代謝変調に反応し,高腫瘍対正常比で腫瘍局所化された光を in vivo で生成した.
結論:
- DHM-NO2は,乳がんにおけるNTR活性をモニタリングするための敏感で選択的なNIR-I光センサーです.
- 探査機の設計は,以前の制限を克服し,腫瘍代謝と治療反応の効果的なイメージングを可能にします.
- DHM-NO2は標準的な光器具と互換性があり,臨床翻訳を容易にする.
関連する概念動画
What is Natural Selection?
129.8K
Natural selection is an evolutionary process in which individuals with survival-promoting traits reproduce at higher rates. These favorable traits become more common within a population or species. Naturally selected traits initially arise via random genetic mutations. In order for selection to occur, there must be variation within a population, the trait controlling the variation must be heritable, and there must be an evolutionary advantage for variation in the trait.
129.8K
Antibiotic Selection
60.2K
Overview
60.2K
Types of Selection
45.3K
Natural selection influences the frequencies of particular alleles and phenotypes within populations in several different ways. Primarily, natural selection can be directional, stabilizing, or disruptive. Directional selection favors one extreme trait and shifts the population towards that phenotype while selecting against individuals displaying alternate traits. Stabilizing selection favors an intermediate trait with a narrow range of variation. Deviation from the optimal phenotype towards an...
45.3K
Frequency-dependent Selection
24.2K
When the fitness of a trait is influenced by how common it is (i.e., its frequency) relative to different traits within a population, this is referred to as frequency-dependent selection. Frequency-dependent selection may occur between species or within a single species. This type of selection can either be positive—with more common phenotypes having higher fitness—or negative, with rarer phenotypes conferring increased fitness.
24.2K
Labeling DNA Probes
9.5K
DNA probes are fragments of DNA labeled with a reporter tag to enable their detection or purification. The resulting labeled DNA probes can then hybridize to target nucleic acid sequences through complementary base-pairing, and may be used to recover or identify these regions.
Radioisotopes, fluorophores, or small molecule binding partners like biotin or digoxigenin, are the most widely used reporter tags for labeling DNA probes. These labels can be attached to the probe DNA molecule via...
Radioisotopes, fluorophores, or small molecule binding partners like biotin or digoxigenin, are the most widely used reporter tags for labeling DNA probes. These labels can be attached to the probe DNA molecule via...
9.5K
Natural Selection and Adaptation
1.5K
Natural selection, a fundamental concept in evolutionary biology, is the mechanism by which evolution is driven, favoring organisms that are best adapted to their environments. This process enhances their chances of survival and reproduction. Adaptation, a key outcome of this process, involves genetic modifications that optimize an organism's functionality under specific environmental challenges, such as extreme cold or thinner air at high altitudes.
Beyond physical adaptations,...
Beyond physical adaptations,...
1.5K

