多価ワクチン接種プロトコルがBos indicusの雌牛の生殖能力に与える影響
Rodrigo de Morais1, Fúlvio Picanço Florenzano2, Adryele Araujo Borges Lima3
1Graduate Program in Animal Reproduction in the Amazon (ReproAmazon), Institute of Animal Health and Production (ISPA), Federal Rural University of the Amazon (UFRA), Belém, PA, Brazil; Federal Institute of Education, Science and Technology of Pará (IFPA), Marabá, PA, Brazil.
Animal reproduction science
|February 12, 2026
まとめ
この研究では,肉牛の生殖健康のために多価ワクチンを評価しました. 初期生殖能力は変化を示さなかったが,ワクチン接種した牛は妊娠率が改善し,第2回授精後に妊娠喪失が減少し,安全性と被曝群の潜在的な利益を示した.
科学分野:
- 獣医免疫学 獣医免疫学について
- 生殖生物学 生殖生物学
- 牛の健康管理について
背景:
- 牛のアルファヘルペスウイルス1 (BoHV-1),牛のウイルス性下痢ウイルス (BVDV),LeptoSpira spp.,Campylobacter fetusなど,牛肉牛の群れにおける生殖疾患は,群れの生産性に重大な影響を及ぼします.
- これらの薬物の高いワクチン接種前の血清流行率は,研究されたボス・インディカス集団内の広範な自然暴露を示唆しています.
- 多価性の生殖予防接種プログラムの有効性を評価することは,群れの生殖能力を改善するために非常に重要です.
研究 の 目的:
- 肉牛と雌牛の生殖能力に対する多価生殖予防接種プログラムの影響を評価する.
- ボス・インディカスの集団で,定時人工授精 (TAI) を受けているボス・インディカスの集団で,BoHV-1,BoHV-5,BVDV-1,BVDV-2,Leptospira spp.,およびC. fetusに対するワクチン接種の安全性と有効性を決定する.
主な方法:
- 合計1217頭の肉牛と雌牛が2つの連続したTAIプロトコルを受けられました.
- ワクチン接種は,TAIの21〜30日前の初回接種,0日目のブースター接種,その後レプトスピラ spp.のブースター接種でした. 妊娠中に.
- AI (P/AI) による妊娠は,超音波検査とパルパーションによって評価され,出産までの産卵率が監視されました.
主要な成果:
- ワクチン接種と対照群の間の最初のTAI後にP/AIの有意な違いは観察されなかった.
- 2回目のTAIの後,ワクチン接種を受けた動物は120日後にP/AIが高く (P=0.03) 妊娠中絶が30日~120日間で減少した.
- ワクチン接種前の抗体タイトルの高さは,群れ内の標的病原体に対する実質的な以前の暴露を示唆しています.
結論:
- 多価無活性化生殖ワクチン接種は,ボス・インディクス (Bos indicus) の肉牛にとって安全です.
- ワクチン接種は,生殖系病原体への自然曝露が高い群れにおいて,免疫的安定性を高める可能性があります.
- ワクチンの直接的な生殖能力への影響は,特に既にある免疫を持つ集団では,限られているようですが,後期の生殖段階での利点を示しています.
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