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Updated: Feb 14, 2026

In Vitro Analysis of E3 Ubiquitin Ligase Function
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In Vitro Analysis of E3 Ubiquitin Ligase Function

Published on: May 14, 2021

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様々なE3リガゼの探査によってKRAS-G12Dの退廃因子の発見

Hyerin Yim1, Xiangyang Song1, Yue Zhong1

  • 1Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Science, Oncological Science and Neuroscience, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.

European journal of medicinal chemistry
|February 12, 2026
PubMed
まとめ

KRAS-G12Dを標的とする新しいPROTACは,CRBNとVHL E3リガゼを使用して開発され,強力な劣化を示しています. E3リガゼの選択は,効果的なKRAS-G12D分解剤の開発に不可欠です.

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