経皮電気神経刺激は,多発性硬化症の疲労した人の歩行を改善する:ランダム化制御試験
Nikki Dreijer1, Leda B Maffei1, Menno P Veldman2
1Department of Biomedical Sciences, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands; MS Center Noord Nederland, Groningen, the Netherlands.
Annals of physical and rehabilitation medicine
|February 12, 2026
まとめ
休息中に適用された皮膚経電気神経刺激 (TENS) は,多発性硬化症 (pwMS) の患者の歩行能力を改善しました. TENSは,偽刺激と比較して,疲労や歩行制限の認識を有意に改善しませんでした.
科学分野:
- 神経学 神経学とは
- リハビリテーション医学 リハビリテーション医学
- バイオメディカルエンジニアリング
背景:
- 多発性硬化症 (pwMS) は,歩行困難と疲労により,日常生活に重大な影響を及ぼします.
- 経皮電気神経刺激 (TENS) などの非薬理学的戦略は,センソモーター経路経由で運動機能を強化するために調査されています.
- pwMSにおける移動能力と疲労に対するTENSの影響を理解することは,生活の質を改善するために不可欠です.
研究 の 目的:
- pwMSにおける歩行能力と疲労に対するTENSの有効性を評価する.
- 休憩中に適用されたTENSと,同時に運動した時の偽刺激を比較する.
- pwMS.における運動障害に対するTENSが優れた非薬理学的介入を提供しているかどうかを判断する.
主な方法:
- ランダム化され,二重盲検され,80 pwMSの疲労と歩行困難を含む偽薬対照試験.
- 参加者はTENSのみ,TENS+運動,偽刺激,または偽+運動グループに分けられました.
- 介入は4週間にわたって12回の10分間のセッションで構成され,アウトカムがベースライン,介入後,およびフォローアップで評価されました.
主要な成果:
- 休憩中に適用されたTENSは,偽刺激と比較して歩行距離 (6分歩行テスト) を大幅に改善しました.
- TENSグループでは,より高い割合の参加者が,歩行距離の臨床的に有意義な改善を達成しました.
- グループ間の主観的な疲労度または歩行制限の知覚において,有意な差異は観察されなかった.
結論:
- 休憩TENSは, pwMSにおける歩行パフォーマンスの向上の可能性を示しています.
- 運動中に適用されたTENSは,シャムと比較して歩行パフォーマンスの有意な利点をもたらさなかった.
- TENSが運動機能に及ぼす影響の基礎となる神経生理学的メカニズムを明らかにするために,さらなる研究が必要である.
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