関連する実験動画

Updated: Feb 14, 2026

Kinetic Measurement and Real Time Visualization of Somatic Reprogramming
08:56

Kinetic Measurement and Real Time Visualization of Somatic Reprogramming

Published on: July 30, 2016

7.0K

時間だけが教えてくれる:共振性阻害剤の運動学をモデル化する

Madeeha I Ali1,2, Peter J Tonge1,2,3

  • 1Department of Chemistry, Stony Brook University, Stony Brook, New York, USA.

British journal of pharmacology
|February 12, 2026
PubMed
まとめ

薬剤の発見はしばしば結合キネティクスを見逃すが,これは共振性阻害剤にとって極めて重要です. このレビューは,不可逆的な抑制を測定する方法を詳細に説明し,薬剤の有効性を最適化するための運動学第一のアプローチを提案しています.

キーワード:
結合運動学が結合する.協和性阻害剤を併用する.逆戻りできない阻害です.非均衡状態である.ゆっくりと発症する.時間に依存する薬物活動.

さらに関連する動画

Technical Aspect of the Automated Synthesis and Real-Time Kinetic Evaluation of [11C]SNAP-794109:50

Technical Aspect of the Automated Synthesis and Real-Time Kinetic Evaluation of [11C]SNAP-7941

Published on: April 28, 2019

8.0K
Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly09:34

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

Published on: February 6, 2020

8.0K

関連する概念動画

Covalent Bonds01:29

Covalent Bonds

Overview
164.4K
Covalent Bonds01:08

Covalent Bonds

Overview
When two atoms share electrons to complete their valence shells, they create a covalent bond. An atom's electronegativity—the force with which shared electrons are pulled towards an atom—determines how the electrons are shared. Molecules formed with covalent bonds can be either polar or nonpolar. Atoms with similar electronegativities form nonpolar covalent bonds; the electrons are shared equally. Atoms with different electronegativities share electrons unequally,...
11.9K
Network Covalent Solids02:18

Network Covalent Solids

Network covalent solids contain a three-dimensional network of covalently bonded atoms as found in the crystal structures of nonmetals like diamond, graphite, silicon, and some covalent compounds, such as silicon dioxide (sand) and silicon carbide (carborundum, the abrasive on sandpaper). Many minerals have networks of covalent bonds.
To break or to melt a covalent network solid, covalent bonds must be broken. Because covalent bonds are relatively strong, covalent network solids are typically...
16.2K
Covalent Bonding and Lewis Structures02:46

Covalent Bonding and Lewis Structures

Compared to ionic bonds, which results from the transfer of electrons between metallic and nonmetallic atoms, covalent bonds result from the mutual attraction of atoms for a “shared” pair of electrons.
63.0K
Covalently Linked Protein Regulators02:04

Covalently Linked Protein Regulators

Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
These groups modify specific amino acids in a protein....
9.7K
Kinetic Energy00:23

Kinetic Energy

Kinetic energy is the ability of an object in motion to do work or enact change. It can take on many forms. For instance, water flowing down a waterfall has kinetic energy. In biological systems, particles of light travel and are absorbed by plants to create chemical energy. Animals consume the chemical energy and give off molecules that carry their scent through the air. They also generate kinetic energy when they run away from predators. Entire systems also possess kinetic energy, like the...
43.7K