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Updated: Feb 14, 2026

Synthesis of Protein Bioconjugates via Cysteine-maleimide Chemistry
09:14

Synthesis of Protein Bioconjugates via Cysteine-maleimide Chemistry

Published on: July 20, 2016

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システインのシステマティック・スキャニングは,腫瘍性KRASにおける薬物投与可能なポケットを特定します

Laurens M van Tienen1, Shadwa Bayoumi2, Khaja Muneeruddin3

  • 1The Broad Institute of MIT and Harvard, Cambridge, MA, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.

Cell chemical biology
|February 12, 2026
PubMed
まとめ

アクセシブルポケットのシステインマッピング (CysMAP) は,タンパク質の新薬標的を特定します. この方法により,KRAS (G12D) 変種に新しい結合ポケットが発見され,困難な標的に対する治療開発が進められました.

キーワード:
クラス・クラス (Kras Kras) とはコバレンツ化合物とは,コバレンツ化合物のことです.システインスキャニング完ぺきな質量スペクトロメトリーです.スクリーニング・スクリーニング

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