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Updated: Feb 14, 2026

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Porcine As a Training Module for Head and Neck Microvascular Reconstruction
Published on: September 29, 2018
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修復性フラップ手術後の頭頸部放射線療法:多中心型XFLAP1研究の結果
Di Rito Alessia1, Blache Alice2, Preudhomme Renaud3
1Radiation Oncology Unit, Hospital "Mons. A.R. Dimiccoli" - Barletta, Italy.
まとめ
頭頸部がん (HNC) の局所的な再発は,フラップの体内ではめったに起こらない. 放射線治療の標的を原生組織とフラップの接点に集中させることで,副作用を軽減することができます.
科学分野:
- 腫瘍学 腫瘍学
- 外科腫瘍学外科腫瘍学
- 放射線腫瘍学 放射線腫瘍学
背景:
- 頭頸部がん (HNC) の再建手術は,手術後の標的の定義に課題を提示しています.
- 放射線治療の計画において,フラップ全体を含めるべきか,それともネイティブ・ティスイ・フラップ・ジャンクションに集中すべきかについては,議論がある.
研究 の 目的:
- HNC患者のフラップに関連した再発パターンを定量化するために.
- フレップ再建と放射線治療の後の現在の実践,毒性,および機能的アウトカムを要約します.
主な方法:
- 355人のHNC患者を含むXFLAP1コホート (2018-2023) の遡及的分析.
- 患者は,フラップの再建と術後の放射線療法 (PORT) ±化学療法による腫瘍切除を受けた.
- 競合するリスクとKaplan-Meier方法を使用して,局域的な再発 (LRR),転移,全生存 (OS) を分析しました.
主要な成果:
- フリーフラップは67%で,地域ペディクルフラップは33%で使用されました.
- 再発の1%のみ (3/355) がフラップボディ内で発生し,ほとんどの局所的な障害はネイティブ組織-フラップの交差点にあった.
- 2年間の累積発生率は,LRRの15.8%,転移の16.7%であり,2年間のOSは74.6%であった.
結論:
- フラップボディのエピセンターでの再発は,HNC患者ではまれである.
- 現在のデータは,臨床標的体積 (CTVs) をネイティブ組織-フラップの交差点にフォーカスすることを示唆しています.
- このアプローチは,治療に関連する罹患率を制限するのに役立つ可能性があり,将来の検証を待っている.
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