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Updated: Feb 14, 2026

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles
08:03

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Published on: December 1, 2016

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キノキサリンベースのUCHL5阻害剤は,20S阻害を超えて,次世代のタンパク質を標的とする抗がん剤として使用されています

Tae-Hee Han1, Joohan Lee2, Joo-Young Im3

  • 1Biotherapeutics Translational Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, South Korea; Department of Biomolecular Science, KRIBB School of Bioscience, Korea National University of Science and Technology (UST), Daejeon 34113, South Korea.

Journal of advanced research
|February 12, 2026
PubMed
まとめ

新種のキノキサリン誘導体であるDK-7は,プロテアソームの成分であるUCHL5を選択的に抑制する. この化合物は,がん細胞のアポプトシスを効果的に誘発し,ボルテゾミブ耐性を克服し,固体腫瘍治療の有望性を示しています.

キーワード:
19Sプロテアソマルデウビキチナゼ UCHL55ボルテゾミブに対する耐性があります.プロテアソーム阻害剤 プロテアソーム阻害剤キノキサリンベースの小分子DK-7ウビキチンプロテアソームシステム

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