慢性疼痛と認知症の間のうつ病のメディエーションの二重経路モデル

Ying Tan¹, Shiyu Chen¹, Qi Tian¹

¹Department of Geriatrics, Laboratory of Research and Translation for Geriatric Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.

Experimental gerontology

|February 12, 2026

まとめ

慢性痛は認知症のリスクを高め,痛みの持続時間が長くなり,より大きな脅威となる. うつ病は,より短い疼痛期間におけるこのリンクを完全に媒介しますが,より長い期間においては部分的にのみ媒介します.

科学分野:

ゲロントロジーはゲロントロジーの学科です.
神経科学は神経科学である.
公衆衛生は公衆衛生である.

背景:

慢性疼痛は認知機能低下と認知症の既知の危険因子です.
うつ病は,しばしば慢性疼痛と認知症の関係を媒介する.
認知症の発症における慢性疼痛の持続期間によって異なるうつ病の特定の役割は,完全に理解されていません.

研究の目的:

慢性疼痛の持続時間と認知症のリスクとの関連を調査する.
慢性疼痛から認知症への経路におけるうつ病の媒介的な役割を,さまざまな疼痛期間において調べる.

主な方法:

45歳以上の成人の1096人の横断分析.
慢性疼痛は3ヶ月以上の痛みとして定義され,持続時間 (3〜24ヶ月, >24ヶ月) によって分類されます.
認知症はミニメンタルステート検査 (MMSE) によって評価され,うつ病は患者健康アンケート-9 (PHQ-9) によって評価されました.
統計分析には,ロジスティック回帰とメディエーション分析が含まれていました.

主要な成果:

認知症の罹患率は,慢性疼痛を有する個体において有意に高かった.
慢性疼痛の持続期間が長い (>24ヶ月) は,より短い期間 (3〜24ヶ月,OR=1.78) に比べて認知症のリスクが著しく高かった (OR=2.60).
鬱病は,慢性疼痛と認知症の関連性を,3~24ヶ月間,部分的に24ヶ月以上の間,完全に媒介した.

結論:

慢性疼痛の持続期間は,認知症のリスクと有意に関連しています.
うつ病は,慢性疼痛と認知症の関係において,痛みの持続時間によって変化する,異なる媒介的な役割を果たします.

キーワード:

慢性的な痛み慢性的な痛み認知症認知症とはうつ病うつ病うつ病うつ病調停分析調停分析調停分析

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