臨床的に安定したCFの成人と健康な対照群における肺クリアランス指数の試験間再現性
Chantal Darquenne1, Janelle M Fine1, Ann R Elliott1
1Department of Medicine, University of California, San Diego, CA 92093-0623, United States.
まとめ
複数の呼吸窒素洗浄 (MBW) は,システィックフィブロシス (CF) の成人および健康な個体において良好なテスト-リテスト再現性を示しています. 肺クリアランス指数 (LCI) の15%以上の変化は生理学的に重要なものとみなされます.
科学分野:
- 肺内医学 肺内医学 肺内医学
- 呼吸器生理学 呼吸器生理学について
- クリニカル診断士
背景:
- 多重呼吸窒素洗浄 (N2 MBW) と肺クリアランス指数 (LCI) は,臨床環境でますます利用されています.
- 成人のN2MBWのインターテスト再現性に関する縦断的なデータは限られている.
研究 の 目的:
- 囊性線維症 (CF) と健康な対照群の成人のMBWパラメータのN2のインターテスト再現性を評価する.
- 機能的残留容量 (FRC),LCI,およびアルベオラ混合効率 (AME) の生物学的変動性を決定する.
主な方法:
- N2 MBWテストは,安定したCF患者の41人と健康なコントロールの56人に3回実施されました.
- FRC,LCI,およびAMEの測定は,商用デバイスを使用して,3-6週間の間隔で2回の訪問の間に行われました.
主要な成果:
- CFの患者は,対照群と比較して,より高いLCIとより低いAMEを示した.
- 訪問の間のFRC,LCI,AMEの平均差は,両方のグループでほぼゼロでした.
- 生物学的変動率は,コントロール群でLCIで±15%,AMEで±4%,CF患者でLCIで±18%,AMEで±9%でした.
結論:
- N2 MBWは,健康で臨床的に安定したCFの成人の3〜6週間の間にわたって,LCIとAMEの同様の再現性を示しています.
- LCIのパーセンテージの変化が±15%を超えると,生理学的に関連性があり,商用デバイスで使用されるテストの生物学的変動性を上回ります.
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