Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Fruit Development, Structure, and Function01:58

Fruit Development, Structure, and Function

25.4K
Fruits form from a mature flower ovary. As seeds develop from the ovules contained within, the ovary wall undergoes a series of complex changes to form fruit. In some fruits, such as soybeans, the ovary wall dries; in other fruits, such as grapes, it remains fleshy. In some cases, organs other than the ovary contribute to fruit formation; such fruits are called accessory fruits.
25.4K
Structural Protein Function01:56

Structural Protein Function

30.1K
Structural proteins are a category of proteins responsible for functions ranging from cell shape and movement to providing support to major structures such as bones, cartilage, hair, and muscles. This group includes proteins such as collagen, actin, myosin, and keratin.
Collagen, the most abundant protein in mammals, is found throughout the body. In connective tissue, such as skin, ligaments, and tendons, it provides tensile strength and elasticity.  In bones and teeth, it mineralizes to...
30.1K
Structural Protein Function01:56

Structural Protein Function

3.3K
3.3K
Structure and Function of Erythrocytes01:29

Structure and Function of Erythrocytes

6.2K
There are between 4.2 and 6 million erythrocytes, also known as red blood cells, in every microliter of blood. These cells are small, flattened biconcave discs with centers that are depressed.
The erythrocyte plasma membrane is associated with proteins such as spectrin, which forms a flexible cytoplasmic meshwork. This meshwork allows erythrocytes to twist, turn, become cup-shaped, and regain their biconcave shape as they pass through narrow capillaries. Additionally, erythrocytes can form...
6.2K
Structure and Function of Platelets01:18

Structure and Function of Platelets

3.8K
The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000...
3.8K
Structure and Function of Leukocytes01:21

Structure and Function of Leukocytes

4.5K
An adult in good health typically has between 4,500 and 11,000 leukocytes, or white blood cells, per microliter of blood, which constitutes about 1% of the total blood volume. Unlike red blood cells, white blood cells contain a nucleus and other cellular organelles but do not have hemoglobin. Most white blood cells reside in connective tissues, particularly in lymphatic organs such as the lymph nodes, with only a small fraction present in circulating blood.
White blood cells protect the body...
4.5K

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Beyond AI-Driven Curve Fitting: Mechanistic Insight as the Cornerstone of Reliable Sensing and Accurate Fitting.

Small methods·2026
Same author

Seven Models for Outer Surface-Only Functionalized Nanofluidic Systems.

ACS nano·2026
Same author

Site-specific post-translational modification detection by polar charged engineered MspA nanopores.

Chemical science·2026
Same author

Dual-Interface Nanopore Array Sensor Revealing the Synergistic Oscillations of Lactate Efflux in Cancer Cells.

Angewandte Chemie (International ed. in English)·2026
Same author

A robust Au-C[triple bond, length as m-dash]C anchoring group greatly improves the signal stability of electrochemical aptamer-based sensors for <i>in vivo</i> measurements.

Chemical science·2026
Same author

Assessment of Robustness of MRI Radiomic Features in Four Abdominal Organs: Impact of Deep Learning Reconstruction and Segmentation.

Journal of magnetic resonance imaging : JMRI·2026

関連する実験動画

Updated: Feb 14, 2026

A Flow Cytometry-Based Cell Surface Protein Binding Assay for Assessing Selectivity and Specificity of an Anticancer Aptamer
10:46

A Flow Cytometry-Based Cell Surface Protein Binding Assay for Assessing Selectivity and Specificity of an Anticancer Aptamer

Published on: September 13, 2022

4.4K

外部表面のスーパーサンドイッチ構造のアプタマー機能化されたナノチャネルで,高度に特異的なセンシングを行う.

Zhengxu He1, Defang Ding1, Daisan Zha1

  • 1State Key Laboratory of Geomicrobiology and Environmental Changes, Engineering Research Center of Nano-Geomaterials of Ministry of Education, Faculty of Material Science and Chemistry, China University of Geosciences, Wuhan 430074, P. R. China.

Analytical chemistry
|February 12, 2026
PubMed
まとめ

この研究では,毒性汚染物質の検出を強化するために,スーパーサンドイッチDNAアプタマーを使用する新しいナノチャネルセンサーを導入しています. センサーは,改善された現実世界の水サンプル分析のためにDNAの構成変化を活用することによって,優れた特異性を達成します.

さらに関連する動画

A Method for Selecting Structure-switching Aptamers Applied to a Colorimetric Gold Nanoparticle Assay
12:31

A Method for Selecting Structure-switching Aptamers Applied to a Colorimetric Gold Nanoparticle Assay

Published on: February 28, 2015

15.7K
Multiscale Structures Aggregated by Imprinted Nanofibers for Functional Surfaces
06:14

Multiscale Structures Aggregated by Imprinted Nanofibers for Functional Surfaces

Published on: September 11, 2018

7.0K

関連する実験動画

Last Updated: Feb 14, 2026

A Flow Cytometry-Based Cell Surface Protein Binding Assay for Assessing Selectivity and Specificity of an Anticancer Aptamer
10:46

A Flow Cytometry-Based Cell Surface Protein Binding Assay for Assessing Selectivity and Specificity of an Anticancer Aptamer

Published on: September 13, 2022

4.4K
A Method for Selecting Structure-switching Aptamers Applied to a Colorimetric Gold Nanoparticle Assay
12:31

A Method for Selecting Structure-switching Aptamers Applied to a Colorimetric Gold Nanoparticle Assay

Published on: February 28, 2015

15.7K
Multiscale Structures Aggregated by Imprinted Nanofibers for Functional Surfaces
06:14

Multiscale Structures Aggregated by Imprinted Nanofibers for Functional Surfaces

Published on: September 11, 2018

7.0K

科学分野:

  • ナノテクノロジー ナノテクノロジー
  • バイオセンシング (biosensing) とは
  • 環境科学 環境科学

背景:

  • 固体ナノチャネルセンサーは,有毒汚染物質の検出に高い感度を提供します.
  • 具体性の強化とその基礎となるメカニズムは,重要なが,しばしば見過ごされる研究分野である.
  • 既存の方法は,構造的に似た汚染物質を区別するのに苦労しています.

研究 の 目的:

  • 毒性汚染物質の検出のための特異性を強化した双面改変ナノチャネルセンサーを開発する.
  • スーパーサンドイッチDNAアプタマーを用いて特異性増強のメカニズムを調査する.
  • リアルな世界での水のサンプルを検知するための携帯可能で現場での検知方法を作成する.

主な方法:

  • Cu-TCPPの金属有機フレームワーク (MOF) が,アノード性アルミニウム酸化物 (AAO) ナノチャネルでインシット成長.
  • スーパーサンドイッチ構造DNA (SSW-DNA) アプタマープローブによるナノチャネルの機能化.
  • センサーの性能とマイクロシスティンの変種に対する特異性を評価するためのイオン電流測定.

主要な成果:

  • SSW-DNA@MOFsのナノチャネルセンサーは,ssDNA@MOFsと比較して,マイクロシスティン-LR (MC-LR) に対してマイクロシスティン-RR (MC-RR) に対する特異性が著しく向上した.
  • イオン電流の変動率は,SSW-DNA@MOFs (15.15% vs. 9.44%) よりもSSW-DNA@MOFs (48.20% vs. 10.60%) でMC-LRとMC-RRを検知する際により大きな不一致を示しました.
  • 強化された特異性は,ターゲットの結合時にSSW-DNAプローブの明確な形状の変化に起因し,実際の最初のインターフェイスで表面電荷密度のより大きな変化につながります.

結論:

  • スーパーサンドイッチDNAアプタマー機能化は,ナノチャネルセンサーの特異性を効果的に強化します.
  • SSW-DNAプローブの形状の変化は,実際の最初のインターフェースで検出特異性を向上させるための鍵です.
  • 開発されたポータブルナノチャネルセンサーは,複雑な環境サンプルにおける有毒汚染物質の現場検出の可能性を示しています.