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Updated: May 5, 2026

Detection of Disease-associated α-synuclein by Enhanced ELISA in the Brain of Transgenic Mice Overexpressing Human A53T Mutated α-synuclein
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Detection of Disease-associated α-synuclein by Enhanced ELISA in the Brain of Transgenic Mice Overexpressing Human A53T Mutated α-synuclein

Published on: May 30, 2015

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グルコシルセラミド誘発のエクトソームは,パーキンソン病における病原性α-シヌクレインを伝播する

Julie Jacquemyn1,2,3,4, Brian Marriott1,4, Jinlan Chang1

  • 1Department of Physiology, University of Alberta, Edmonton, Alberta, Canada.

Nature cell biology
|February 12, 2026
PubMed
まとめ

パーキンソン病は,アルファ-シヌクレインの拡散を伴う. 変化した脂質,特にベータ-グルコセレブロシダースの活性が低下したためグルコシルセラミドが増加すると,アルファ-シヌクレイン伝播の重要な経路であるエクトソームの放出を促進します.

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