高齢者の皮質構造と妄想を結びつける:コホート研究と共有された遺伝的リスク分析からの洞察

Yanbo Chen¹, Jiayuan Zheng¹, Runnan Shen²

¹Department of Trauma Orthopedics, Foot and Ankle Surgery, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, China.

Journal of translational medicine

|February 12, 2026

まとめ

高齢者における皮質の厚さと体積の減少は,妄想症のリスクが高いことと関連しています. 脳磁気共鳴画像 (MRI) は,高齢の患者の術前妄想リスク評価に役立ちます.

科学分野:

神経画像は,神経イメージングによるものです.
ゲリアトリック・メディシン (老年医学)
遺伝学遺伝学とは

背景:

妄想症は,高齢の患者,特に術後における一般的な合併症です.
妄想リスクの信頼できるバイオマーカーを特定することは,予防戦略にとって極めて重要です.

研究の目的:

脳の構造の変化と妄想の発生率との関連を調査する.
皮質構造と妄想リスクの遺伝的基盤を探求する.

主な方法:

ベースラインの脳MRIデータを使用した潜在的なコホート (英国バイオバンク,独立した臨床コホート) を利用しました.
抽出地域皮質の体積,厚み,表面積は,デシカン-キリアーニ・アトラスを用いて抽出した.
コンド/コンジFDR分析によるロジスティック回帰と全ゲノム関連研究 (GWAS) を実施しました.

主要な成果:

17の領域における皮質の厚さの減少は,英国バイオバンクコホートにおける妄想症のリスクの増加と相関していた.
7つの領域における皮質の体積の減少は,独立したコホートにおいて,より高い妄想リスクと関連していた.
皮質構造と妄想に関連した100のSNPを特定し,NT5C2やCCDC25のような遺伝子を関与させた.

結論:

地域皮質縮は,高齢者集団における妄想の重要なリスク因子である.
脳MRIは,年配の外科患者の術前妄想リスクの階層化に貴重なツールとして役立つかもしれません.

キーワード:

脳の構造脳の構造デリリウム・デリリウム遺伝的相関関係遺伝的相関関係神経画像は,神経イメージングによるものです.イギリスのバイオバンク

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