尿道菌の微生物群と膀の過剰活動,抗生物質と治療への反応との関連

Glenn T Werneburg^1,2, Michael D Gross¹, Daniel R Hettel¹

¹Department of Urology, Glickman Urological Institute, Cleveland Clinic, Cleveland, Ohio, USA.

Neurourology and urodynamics

|February 13, 2026

まとめ

尿路のミコバイオームは,健康な女性と,過活動性膀 (OAB) を有する女性の間で異なる. 菌類は,尿路の微生物群内の複雑な相互作用において重要な役割を果たします.

科学分野:

泌尿器科泌尿器科とは
微生物学微生物学とは
菌類学菌類学とは

背景:

菌類 (ミコバイオーム) を含む尿道微生物群は,健康と病気における役割としてますます認識されています.
過度に活発な膀 (OAB) は,生活の質に影響を与える一般的な状態であり,その根本的なメカニズムは完全に理解されていません.

研究の目的:

尿道菌群をOABとOABのない女性で特徴づけ,比較する.
ミコビオームとOAB併発症,抗生物質の曝露,治療への反応との関連を調査する.

主な方法:

152人の女性 (OABとOABなし) の尿サンプルを内部転写スペーサー (ITS) 配列を用いて真菌DNAを特定するために分析した.
菌類の多様性,相対的多量,および王国間の菌類と細菌の相互作用が評価されました.

主要な成果:

菌類は98%のサンプルで検出され,バシジオミコタとアスコミコタが支配的な属である.
カンジダやデバリオマイセスのような特定の属は,OABと健康なグループ間の差異的な豊富さを示しました.
尿系ミコバイオームの構成は,OAB状態,糖尿病,抗生物質の使用,治療結果によって変化し,微生物コミュニティにおける真菌の中心的な役割を強調した.

結論:

この研究では,OABとOABのない女性の尿路キノコの特徴的なプロファイルが明らかになりました.
菌類は,尿路の王国間微生物ネットワークに不可欠です.
これらの発見は,泌尿器疾患に対する尿路菌群内の潜在的な治療標的を示唆しています.

キーワード:

バクテリアバクテリアバクテリアバクテリアバクテリアバクテリアバクテリア菌類菌類は,菌類が作るものです.微生物群 (microbiome) とは,微生物の集合体である.マイコバイオーム (Mycobiome) とはマイコバイオータ (Mycobiota) とは活動過度の膀は,過度に活動している.

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