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Updated: Feb 14, 2026

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腸内薬物投与の最適化:商用腸内カプセルと,強化精密医療のためのカスタマイズ可能な放出プロファイルを持つ3Dプリントカプセルを比較した研究
Devansh Sharma1, Shantanu G Gaurkhede2,3, Jia Deng2
1Department of Pharmaceutical Sciences, Massachusetts College of Pharmacy and Health Sciences, Boston, MA 02115, USA.
Materials (Basel, Switzerland)
|February 13, 2026
まとめ
pH反応性ポリマーを使用した3Dプリントされたカプセルは,従来のゼラチンカプセルとは異なり,制御された薬剤の放出を提供します. この3Dプリント技術により,精密医療の調整可能な,患者特有の用量形態が可能になります.
科学分野:
- 医薬品科学 医薬品科学とは
- 材料科学 材料科学とは
- バイオメディカルエンジニアリング
背景:
- 従来のゼラチンカプセルは,胃で薬剤が素早く放出され,制御されたまたは遅延された放出を必要とする治療には適さない.
- 精密医療は,適応された治療結果のために,カスタマイズ可能な薬物投与システムを必要とします.
研究 の 目的:
- 3Dプリントされたカプセル殻を最適化するために,pH反応性ポリマーブレンドを使用して,制御された持続的な薬剤の放出を可能にします.
- 商用腸内カプセルと3Dプリントカプセルの薬物放出プロフィールを比較する.
主な方法:
- カプセルシェルは,2つの異なる比率で,ヒドロキシプロピルメチルセルロースアセテートサクシネート (HPMC-AS),PEG-4000,PVAを併用した溶融フィラメント製造 (FFF) を使用して製造されました.
- アセトアミノフェン (250 mg) をカプセルに詰め込み,シミュレートされた胃液 (SGF) に溶解テストを行い,その後シミュレートされた腸液 (SIF) を実施しました.
主要な成果:
- 3Dプリントされたカプセルと商用カプセルの両方が,SGFにおける薬剤の放出量が軽微 (≤5%) であることを示した.
- SIFでは,商用カプセルは薬剤の迅速な放出を15分で (>80%),3Dプリントカプセルは長期にわたる緩やかな放出を示した.
- 印刷されたカプセルに含まれるHPMC-ASの含有量が高く,薬剤の放出期間を大幅に延長しました.
結論:
- 3Dプリントされたカプセルシェルは,制御可能で持続的な薬物放出プロフィールを成功裏に達成しました.
- 3Dプリント技術は,高度な薬物投与のための調整可能な,患者特有の用量形態を開発するための大きな可能性を秘めています.
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