バンド中性粒子は,ビンクリスティンを含む多剤化学療法を受けている犬に観察されています
Caitlin N Eliason1,2, Steven J Pierce3, Alison Masyr1
1Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824, USA.
Animals : an open access journal from MDPI
|February 13, 2026
まとめ
帯中性子細胞,またはバンドミアは,化学療法を受けている犬で記録されています. 体の表面積が小さくなり,ビンクリスティンやドクソルビシンなどの特定の化学療法薬は,バンド血症の有病率の増加と関連しています.
科学分野:
- 獣医医学 獣医医学は,獣医医学というものです.
- 腫瘍学 腫瘍学
- 血液学 ヘマトロジ
背景:
- 化学療法は一般的に犬のニュートロペニアを誘発します.
- バンデミアによって特徴づけられる左傾きは,化学療法を受けている犬では以前は記録されていません.
研究 の 目的:
- 多剤化学療法を受けている犬の帯中性粒子の上昇の有病率を決定する.
- これらの犬のバンドミア発症に関連する要因を特定するために.
主な方法:
- 2018年から2022年までの医療記録の遡及的レビュー.
- 身体表面積,白血球数,セグメンテッド・アンド・バンド・ニュートロフィール数,投与された化学療法薬の分析.
- 一般化された線形混合モデルを用いた統計分析.
主要な成果:
- バンド中性粒子は,ナディール完全血液検査 (CBC) の20.2%に存在していました.
- バンド中性粒子の増加 (バンドミア) は,CBCの13.6%で発生しました.
- 体の表面積が小さくなると,バンド血症の罹患率が高くなることが分かりました.
- バンデミアは,ビンクリスティンまたはドクソルビシンを投与した後に,サイクロフォスファミドと比較してより一般的であった.
結論:
- 帯中性粒子は,化学療法を受けている犬に存在します.
- バンデミアの罹患率は,体表面積と負の相関関係にある.
- ヴィンクリスティンとドクソルビシンの投与は,バンド血症のより高い罹患率と関連しています.
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