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Updated: Feb 14, 2026

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Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451
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超高速の飛行時間を持つBIOGRAPH One次世代ハイブリッドPET/MRIシステムによる最初の臨床体験
Otto M Henriksen1, Kirsten Korsholm1, Annika Loft1
1Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital Rigshospitalet, 2100 Copenhagen, Denmark.
Diagnostics (Basel, Switzerland)
|February 13, 2026
まとめ
BIOGRAPH One PET/MRIシステムは,体と脳のイメージングの性能を向上させ,以前のモデルよりも優れた画像品質とワークフローの可能性を提供します. この次世代スキャナーは,診断の精度を高め,臨床応用を拡大する可能性があります.
科学分野:
- メディカルイマージング (医学イメージング)
- 核医学は,核医学である.
- 放射線学 放射線学
背景:
- BIOGRAPH Oneは,次世代のPET/MRIシステムを代表しています.
- 臨床的パフォーマンスを評価することは,診断能力を向上させるために極めて重要です.
研究 の 目的:
- 身体と脳のイメージングのためのBIOGRAPH One PET/MRIシステムの臨床性能を評価する.
- PETの画像品質,定量化,および騒音特性を,既定のPET/CTおよび第1世代のPET/MRIシステムと比較するために.
主な方法:
- 59人の患者は,様々なトレーサー ([18F]FDG, [18F]FE-PE2I, [18F]FET, [68Ga]Ga-DOTATOC) を使用してBIOGRAPH One PET/MRIでスキャンを受けました.
- PET画像の品質は視覚的に評価され,参照スキャン (PET/CT,初代PET/MRI) と比較されました.
- 診断コンコンダンス,定量化,画像ノイズが評価されました.
主要な成果:
- スキャンの93%が"良好"または"非常に良好"の画像品質評価を受けました.
- 画像の品質は,99%のケースで参照スキャンと同等またはより良いと評価されました.
- 診断コンコンダランスは99%に達し,画像ノイズはデジタルPET/CTに匹敵し,第1世代のPET/MRIに優れている.
結論:
- BIOGRAPH One PET/MRIは,前作と比較して,PETの感度とワークフローの効率性を向上させました.
- このシステムは,より広範な臨床採用と,医学イメージングにおける研究アプリケーションの拡大の可能性を示しています.
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