ベースラインの腸内微生物群と代謝物質のプロファイルは,ネオアジュバント化学療法を受けている乳がん患者の治療反応と関連しています
Elza Elizabete Liepina1, Elina Sivina1,2, Lelde Jurkane1,3
1Institute of Oncology and Molecular Genetics, Riga Stradins University, Pilsonu Street 13, Block 13, LV-1002 Riga, Latvia.
Diagnostics (Basel, Switzerland)
|February 13, 2026
まとめ
乳がん患者さんには,乳がんの患者さんがいます.
科学分野:
- 腫瘍学 腫瘍学
- マイクロバイオーム研究
- メタボロミクスとは
背景:
- 乳がんにおけるネオアジュバンスト化学療法 (NAC) 反応は変動し,腫瘍因子によって完全に説明されない.
- 化学療法の有効性における腸内微生物群の役割は,ますます認識されていますが,乳がんでは十分に研究されていません.
- 腸内微生物の影響を理解することで,治療戦略を改善することができます.
研究 の 目的:
- NAC.を受ける乳がん患者における腸内微生物の組成と機能を特徴付けるため.
- NAC応答に関連した微生物代謝物を特定するために.
- 三重陰性乳がん (TNBC) のこれらの関連性を調査する.
主な方法:
- ショットガンメタゲノミクシーケンシングと39人の乳がん患者からの基礎的な便サンプルでの標的メタボロミクス.
- 病理学的完全応答 (pCR) に基づく患者の分層化.
- 微生物の多様性,分類学および機能的プロファイル,短鎖脂肪酸 (SCFA),胆酸の分析.
主要な成果:
- pCRを達成した患者で,基線より高い微生物濃度が観察されました.
- 応答者および非応答者において,異なる微生物分類が強化された.
- 特定のSCFAおよび胆酸 (例えばデオキシコール酸) は,反応との異なる関連性を示したが,すべてが修正後に統計的有意性に達したわけではない.
結論:
- 腸内微生物群の基本的特徴 (多様性,構成,機能) は,乳がんにおけるNAC反応と相関しています.
- 腸内微生物とその代謝産物は,NACの有効性を予測するバイオマーカーとして機能する可能性があります.
- マイクロバイオームを標的とした介入に関するさらなる研究は,治療の成果を向上させる可能性がある.
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