光学一貫性トモグラフィーと光学一致性トモグラフィー-血管図 末期腎疾患における慢性的な変化:体系的なレビュー
Ioana-Madalina Bilha1, Stefana Catalina Bilha2, Nada Akad3
1Department of Morpho-Functional Sciences I-Histology and Pathology, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.
Diagnostics (Basel, Switzerland)
|February 13, 2026
まとめ
オプティカルコヒーレンストモグラフィ (OCT) とOCTアニオグラフィ (OCTA) は,末期腎疾患 (ESRD) の患者の慢性マイクロ血管変化を明らかにします. これらの網膜の発見は,慢性腎臓病 (CKD) の全身血管評価とモニタリングを支援する可能性があります.
科学分野:
- オフタルモロジック (眼科)
- ネフロロジーはネフロロジーを用います.
- 血管生物学 血管生物学
背景:
- 末期腎疾患 (ESRD) は,重要なマイクロ血管機能不全を含む.
- 網膜と腎臓のマイクロ循環は類似性を共有しており,眼鏡画像は全身血管損傷の評価に有望である.
研究 の 目的:
- OCTとOCTAを用いてESRDにおける慢性網膜および冠状腺変異を体系的に検討する.
- ESRD患者におけるOCT/OCTAによって検出可能なマイクロ血管変化に関する証拠を統合する.
主な方法:
- OCT/OCTAのESRD患者の研究に関するPubMed/MEDLINE (開始 - 2025年6月) の体系的な文献検索.
- 慢性的なOCT/OCTAの発見を報告する成人の臨床試験を含み,英語以外の報告,急性疾患のみの報告,非臨床的報告を除外する.
- 17件の研究は,合成のための適格性基準を満たした.
主要な成果:
- 一貫した慢性的な構造的および浸透異常が観察されました:網膜神経繊維/ギャングリオン細胞層の薄め,血管密度の低下,状アヴァスキュラーゾーンの拡大,冠状腺の厚さの減少.
- これらの網膜の変化は,ESRDの重症度および全身マイクロ血管負荷と相関しています.
結論:
- OCT/OCTAによる網膜画像は,ESRDにおける再現可能な慢性マイクロ血管変化を示しています.
- 網膜血管スクリーニングは,ESRD/CKD患者における全身血管評価のアクセシブルな補助剤として役立つかもしれません.
- 網膜のバイオマーカーをCKDモニタリングに統合するには,標準化されたイメージングプロトコルが必要です.
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